Chemosynthesis method of 4-bromomethyl-5-methyl-1,3-dioxy heterocyclic pentene-2-ketone

Abstract

The invention provides a chemical synthesis method of 4-bromomethyl-5-methyl-1, 3-dioxa cyclopentene-2-ketone, which comprises using 4, 5-dimethyl-1, 3-dioxa cyclopentene-2-ketone as raw material and uses N-bromosuccinimide as bromination agent to be reacted in the presence of initiator and in organic solvent, separating and purifying the reaction liquor after the reaction, to obtain 4-bromomethyl-5-methyl-1, 3-dioxa cyclopentene-2-ketone. The chemical synthesis method of 4-bromomethyl-5-methyl-1, 3-dioxa cyclopentene-2-ketone has the advantages of reasonable process conditions, reliable and safe production, simple operation, little discharge of three wastes and benefit for industrial production.

Description

(1) Technical field

[0001] The invention relates to a chemical synthesis method of 4-bromomethyl-5-methyl-1,3-dioxol-2-one. (2) Background technology

[0002] 4-Bromomethyl-5-methyl-1,3-dioxol-2-one is mainly used in the synthesis of new semi-synthetic antibiotics, for example, in the synthesis of semi-synthetic penicillin-lenampicillin hydrochloride.

[0003] The existing main method of chemically synthesizing 4-bromomethyl-5-methyl-1,3-dioxol-2-one is obtained by bromine bromination reaction, such as JP 58 152879, 1983, US 4428806, Chem.Pharm.Bull.1984, 32, 6, 2241-2248, etc. Although the bromine bromination method has been widely used in industry, the selectivity of bromine to the allyl position is far worse than that of NBS, the reaction yield is low, and the liquid bromine is too toxic, so the application also has great safety question. Therefore, there are certain limitations in industrial application. (3) Contents of the invention

[0004] The purpose of the pre...

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