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Use of medicament of geldanamycin derivative for preparing medicament for curing chemotherapy induction alopecia

A technology of geldanamycin and methoxygeldanamycin, which is applied in the field of geldanamycin derivatives, can solve problems such as unisolated geldanamycin-resistant strains, and achieve reliable and safe sex, reduce psychological stress, and improve the quality of life

Inactive Publication Date: 2008-09-03
邹江鹰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After 41 passages in vitro, no geldanamycin-resistant strain of HSV-1 was isolated

Method used

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  • Use of medicament of geldanamycin derivative for preparing medicament for curing chemotherapy induction alopecia
  • Use of medicament of geldanamycin derivative for preparing medicament for curing chemotherapy induction alopecia
  • Use of medicament of geldanamycin derivative for preparing medicament for curing chemotherapy induction alopecia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Embodiment: animal model and treatment of alopecia after chemotherapy

[0031] 1. Experimental materials

[0032] The experimental animals were SPF grade Km mice aged 4-6 weeks, provided by the Experimental Animal Center of Sun Yat-sen University, and raised at room temperature.

[0033] Cyclophosphamide and paclitaxel for injection were purchased from Sun Yat-sen University Cancer Hospital, and other commercially available products can also be used;

[0034] Therapeutic drug: 17-propenylamino-17-desmethoxygeldanamycin (17-AAG), purchased from SIGMA Company.

[0035] Others: physiological saline; chloral hydrate; water bath and other heating equipment.

[0036] 2. Experimental methods and results

[0037] The experimental mice were randomly divided into five groups: control group, cyclophosphamide chemotherapy experimental group (no drug treatment), cyclophosphamide chemotherapy + drug treatment group, paclitaxel chemotherapy group (no drug treatment), paclitaxel che...

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Abstract

The invention relates to the new use of geldanamycin derivative, particularly to an application of the geldanamycin derivative in preparing drugs for treating chemotherapy-induced alopecia. The invention provides an application of geldanamycin derivative 17-allylaniino-17-demethoxy-geldanamycin (17-AAG) in preparing drugs for treating chemotherapy-induced alopecia. The inventive geldanamycin derivative 17-AAG can be used for developing new drugs for treating chemotherapy-induced alopecia, which have reliable safety and can remarkably improve the life quality of chemotherapy patients and relieve mental pressure of patients, so as to better cooperate with cancer treatment.

Description

technical field [0001] The present invention relates to the new application of geldanamycin derivatives, especially the application of geldanamycin derivatives in the field of chemotherapy-induced alopecia. Background technique [0002] Hair is composed of the hair root, the hair bulb (germinal center) and the hair shaft. Cells proliferate within the hair bulb, where the hair grows from the root through the scalp. The end result is just a strand of tight keratin. Hair growth is divided into three stages. The first stage is anagen, which is the growth phase and 85-90% of human hair follicles are in anagen. Each hair follicle contains a spherical base of mitotically active mother cells. From these bases, all hair stem cells differentiate and grow. The cells move in rows towards the upper part of the hair bulb and elongate vertically. Eventually they are forced upwards and burrow out of the skin's surface. Human hair bulb cells divide on average every 12 to 24 hours. Du...

Claims

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Application Information

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IPC IPC(8): A61K31/395A61P17/14A61P35/00
Inventor 邹江鹰陈清彬鄂顺梅林锦梅赖坤周帷
Owner 邹江鹰
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