Nutritional supplement for a category of HIV patients

A kind of use, oligosaccharide technology, applied in antiviral agents, applications, metabolic diseases, etc., can solve problems such as improving nutritional status

Inactive Publication Date: 2008-09-10
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] However, while products are available that support the general nutritional needs of HIV-infected patients, there are no nutritional products that both improve nutritional status and additionally significantly reduce or prevent specific HIV-infection-associated symptoms Symptoms specifically refer to the subject's immune dysfunction and optionally refer to intestinal dysfunction and / or glutathione status, and / or transmission of HIV

Method used

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  • Nutritional supplement for a category of HIV patients
  • Nutritional supplement for a category of HIV patients

Examples

Experimental program
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preparation example Construction

[0139] The present invention also provides a method for preparing the composition for treating and / or preventing HIV, the method comprising:

[0140] - providing a suitable amount of one or more oligosaccharides;

[0141] - formulation of the aforementioned components into a suitable food or food supplement or pharmaceutical composition.

[0142] The invention is illustrated in the following examples. The practice of the present invention will employ, unless otherwise indicated, standard conventional methods of molecular biology, pharmacology, immunology, virology, microbiology or biochemistry. These techniques are described in Sambrook and Russell (2001) Molecular Cloning: A Laboratory Manual, Third Edition, Cold Spring Harbor Laboratory Press, NY, in Volumes 1 and 2 of Ausubel et al. (1994) Current Protocols in Molecular Biology, Current Protocols, USA and Remington' s Pharmaceutical Sciences, Mack Publishing Company, Philadelphia, Pa., 17th ed. (1985), Microbiology: A Lab...

Embodiment 1

[0144] Example 1. Blocking the binding of DC-SIGN-Fc with acid oligosaccharides and GOS

[0145] Blocking DC-SIGN has been found to prevent viral translocation from dendritic cells to CD4 T cells. The inventors have surprisingly found that oligosaccharides can block DC-SIGN with varying potency. As shown in Table 1, the acid oligosaccharides (AOS) pectin hydrolyzate had the greatest potency. These results indicated that AOS could prevent the binding of Fc fragment to DC-SIGN at the lowest concentration.

[0146] Table 1. Potency of oligosaccharides for DC-SIGN binding

[0147] Oligosaccharides

I.C.50(μg / ml)

Acid Oligosaccharides (Pectin Hydrolyzate)

200

Galacto-oligosaccharides (trans-galacto-oligosaccharides)

600

FOS (Inulin HP)

＞1000

[0148] Materials and methods:

[0149] The serially diluted oligosaccharide preparations were coated on ELISA plates. Binding of DC-SIGN-Fc was determined by ELISA using anti-DC...

Embodiment 2

[0150] Example 2. Nutritional Bar Composition

[0151] Raw Material Code g / day Protein g / 100g

[0152] Colostrum SR 20.00 15.00 27.38

[0153] Borage Oil (Ropufa 25n-6) 2000342 4.00 0.00 5.48

[0154] EPA-DHA Oil (Maruha) 2001292 6.00 0.00 8.21

[0155] Galacto-oligosaccharide elixir or syrup 2001189 15.38 0.00 21.06

[0156] Inulin (Raftiline HP) 2001190 0.79 0.00 1.08

[0157] Acid oligosaccharides (pectin hydrolyzate) SR 8.54 0.11 11.69

[0158] N-acetyl-cysteine ​​SR 1.83 1.34 2.50

[0159] Fructosestroop JJ 13.20 0.00 18.07

[0160] Glycerin JJ 3.30 0.00 4.52

[0161] kcal En% per day

[0162] Energy Protein 66 26.9

[0163] Energy carbohydrates 82 33.4

[0164] Energy Fat 97 39.7

[0165] 245

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Abstract

The present invention relates to a nutritional product for HIV patients that are not on highly active antiretroviral therapy. More specifically the invention relates to a nutritional composition comprising oligosaccharides. This invention also relates to the manufacture of a nutritional supplement for use in HIV patients.

Description

technical field [0001] The invention relates to a nutritional product for HIV patients. More specifically, the present invention relates to a nutritional composition that provides carefully selected nutritional ingredients that provide specific support for HIV patients with nutritionally related symptoms. The invention also relates to the manufacture of nutritional supplements for HIV patients. Background technique [0002] Infection with the human immunodeficiency virus (HIV) and the development of acquired immunodeficiency syndrome (AIDS) have had profound domestic and global health, social, political, and economic consequences. Worldwide, more than 40 million people are infected with HIV-1, most of whom live in Asia, sub-Saharan Africa and South America. Despite all of the therapeutic advances made in the past decade, including the development of highly active antiretroviral therapy ("HAART"), it remains impossible to eradicate the virus once an individual is infected. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A61P31/18A61K31/70A23L33/00
CPCA61K31/70A61P3/00A61P31/18A61P37/00A61P37/04
Inventor J·加森E·A·F·范托尔J·W·C·西杰本G·沃莱安
Owner NV NUTRICIA
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