Application of dexamethasone and its combination in preparing motion sickness resistant medicament

Abstract

The invention belongs to the field of medical technology and relates to the new use of dexamethasone and the compound of dexamethasone and ginsenoside used for preparing drugs of anti-kinesa. Experiment on animals proves that dexamethasone plays a role in alleviating the symptoms of nausea and vomiting, and the compound of dexamethasone and ginsenoside has a strong synergetic effect on the main drug effect, such as alleviating the symptoms of kinesa in nausea and vomiting and can reduce the dosage of single dexamethasone as well. Compared with scopolamine, a traditional anti-kinesa drug, the compound of dexamethasone and ginsenoside has no side effect of hypersomnia. Dexamethasone and the compound of dexamethasone and ginsenoside can be used for preparing a novel anti-kinesa drug.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new application of dexamethasone and its composition with ginsenoside for preparing anti-motion sickness medicine. Background technique [0002] Motion sickness refers to a series of autonomic nervous system reactions such as dizziness, pale skin, cold sweat, salivation, epigastric discomfort and even nausea and vomiting that occur when people take transportation (such as airplanes, cars, ships) or before. symptoms and signs. Motion sickness is one of the main factors causing non-combat attrition during rapid troop movement, especially crossing the sea and landing on islands. Motion sickness can affect the productivity of maritime operators and the quality of travel of sea tourists. Therefore, anti-motion sickness drugs not only have important uses in national defense construction and military struggle, but also have a wide range of uses in civilian undertakings such as transp...

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Problems solved by technology

[0004] Dexamethasone is a synthetic long-acting glucocorticoid, which is mainly used clinically for anti-inflammation, anti-shock, anti-allergy, and prevention of vomiting caused by radiotherapy and chemotherapy, but so far no dexamethasone has been used to prevent Reports about motion sickness

[0005] Ginsenosides are the extracts of traditional Chinese medicine ginseng. Modern pharmacological studies have found that ginsenosides can up-regulate the expression of glucocorticoid receptors in stressed organisms and promote their transcriptional regulatory activity, which in turn can enhance the body's response to the environment by improving the efficacy of glucocorticoids. Adaptability, so it is called adaptogen-like drug, but there is no relevant report on the prevention of motion sickness

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