Preparation of potassium platinochloride

A technology of potassium chloroplatinite and potassium chloroplatinate, applied in chemical instruments and methods, sodium/potassium compounds, ruthenium/rhodium/palladium/osmium/iridium/platinum compounds, etc., which can solve the lengthy preparation process and concentration limitations , high production cost and other issues, to achieve the effect of good operating environment, low production cost and short preparation process

Active Publication Date: 2008-10-08
兰州金川科技园有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that in the preparation of potassium chloroplatinate solution, hydrochloric acid is used as solvent, and its concentration is strictly limited.
And the preparation process is lengthy and the production cost is high

Method used

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  • Preparation of potassium platinochloride

Examples

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Effect test

preparation example Construction

[0012] A preparation method of potassium chloroplatinite, the preparation process is as follows: using sponge platinum as raw material to prepare chloroplatinic acid solution and potassium chloride solution to prepare potassium chloroplatinate, and then using hydrazine hydrochloride as reducing agent to reduce chloroplatinic acid Potassium for the preparation of pharmaceutical intermediates potassium chloroplatinite. Include the following steps:

[0013] a) Preparation of potassium chloroplatinate: Weigh a certain amount of sponge platinum, wash it, put it into a beaker, add an appropriate amount of aqua regia in batches, heat properly, and the reaction process is based on the principle of uniform bubbling. After the reaction was stopped, concentrated hydrochloric acid was added dropwise under heating and boiling to catch the nitrate until the system no longer emitted brown nitrogen oxides, and then an appropriate amount of water was added to catch the acid. After filtering, ...

Embodiment 1

[0020] Weigh 100g of platinum sponge, wash it, put it into a beaker, add an appropriate amount of aqua regia, and heat it appropriately. The reaction process is based on the principle of uniform bubbling. After the reaction was stopped, the obtained solution was concentrated until crystals were precipitated, concentrated hydrochloric acid was added dropwise to drive the nitrate until the system no longer emitted brown nitrogen oxides, then concentrated until crystals were precipitated, and an appropriate amount of deionized water was added to drive the acid. Filtration, and the filtrate was prepared into a 50g / L solution for later use.

[0021] 80.0 g of potassium chloride was weighed, made into a 20% solution, filtered, and the filtrate was used for later use. The above chloroplatinic acid solution was taken and added dropwise to the potassium chloride solution under stirring, and the solution appeared yellow precipitation. After the dropwise addition, continued stirring for ...

Embodiment 2

[0025] The specific implementation rules are the same as Example 1, the difference is that the input amount of sponge platinum is 500g, the chloroplatinic acid is prepared into a solution of 100g / L, the potassium chloride consumption is 401g, and the solution is made into 20%, and the potassium chloroplatinate is 1200g, 8000ml of distilled water was added, and the amount of reducing agent hydrazine hydrochloride was 136g. The obtained product was sampled for full elemental analysis and XRD detection, platinum content: 46.2%, potassium content: 17.6%, and no compounds other than potassium chloroplatinite were detected. The product yield was 95.0%.

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Abstract

Disclosed is a method for the production of a potassium platinochloride, which relates to a process for preparing a pharmaceutical intermediate potassium platinochloride. The method of preparation is characterized in that the preparation process adopts a spongy platinum as a material to prepare a chloroplatinic acid solution which is reacted with a potassium chloride solution to prepare the potassium chloroplatinite, then a hydrazine hydrochloride is adopted as a reducing agent to reduce the potassium chloroplatinite for preparing the pharmaceutical intermediate potassium platinochloride. The product adopting the method of the invention has a platinum content of 46.9+-0.2 percent and a potassium content of 19.0+-0.2 percent through a total elemental analysis. The total content of metallic impurity is no more than 0.08 percent.

Description

Technical field: [0001] A preparation method of potassium chloroplatinite relates to a preparation method of a pharmaceutical intermediate potassium chloroplatinite. Background technique [0002] Potassium chloroplatinate is an important intermediate in the preparation of antitumor drugs such as carboplatin, cisplatin and oxaliplatin, and has a good market prospect. [0003] At present, regarding the preparation method of potassium chloroplatinite, only a few literatures report the preparation of its laboratory. Some documents mention that potassium chloroplatinate is used as a raw material, and potassium oxalate, hydrazine hydrate and sulfur dioxide are used as reducing agents to synthesize potassium chloroplatinite. Due to the weak reducing ability of potassium oxalate, the main metal content of the synthesized product is difficult to meet the requirements; hydrazine hydrate has strong reducing ability, and needs to be diluted by a certain multiple to meet the reaction re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G55/00C01D13/00
Inventor 李永军武浚刘会基李勇智马正明张玉祥敬春梅王红梅黄良标马天飞
Owner 兰州金川科技园有限公司
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