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Enhanced hair growth composition and enhanced hair growth method

A technology for hair growth and composition, applied in the field of compositions of length and density, capable of solving problems such as side effects, darkening of the iris, eye irritation, etc.

Active Publication Date: 2011-03-30
林蕙君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] When applied to the user's eyelashes, some of the previously mentioned compositions can cause eye irritation and rare side effects such as darkening of the surrounding skin or iris

Method used

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  • Enhanced hair growth composition and enhanced hair growth method
  • Enhanced hair growth composition and enhanced hair growth method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A randomized double-blind clinical trial was conducted on 34 healthy volunteers to evaluate the product, which has the structural name (z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R , E) Eyelash growth-promoting properties of synthetic prostaglandin analogs of -3-hydroxy-4-phenoxy-but-1-enyl)-cyclopentyl)-hept-5-enoic acid acetamide.

[0038] Prepare a placebo solution consisting of the following ingredients.

[0039] Each composition and its corresponding weight percent are as follows:

[0040] Composition Percentage

[0041] Pure water 96.099

[0042] Hydrolyzed Glycosaminoglycans 0.750

[0043] Phenoxyethanol 0.540

[0044] Triethanolamine 0.520

[0045] Acrylates C 10-30 Alkyl Acrylate Crosspolymer 0.500

[0046] C 12-15 Alkyl Benzoate 0.500

[0047] Caprylyl Glycol 0.430

[0048] Panthenol 0.250

[0049] Sodium chloride 0.130

[0050] Biotin 0.100

[0051] Sodium Lactate 0.087

[0052] Sodium pyrrolidone carboxylate (Sodium PCA) 0.032

[0053] Ethanol 0.030 ...

Embodiment 2

[0084] Randomized double-blind clinical trials were used to compare the compounds containing the active agent of the present invention (i.e. (z)-7-((1R, 2R, 3R, 5S)-3,5-dihydroxyl-2-((R, E)-3-hydroxyl - Effect of 4-phenoxy-but-1-enyl)-cyclopentyl)-hept-5-enoic acid acetamide), bimataprost, and placebo on eyelash length. After 4 weeks of use, different concentrations of the active agent of the present invention increased eyelash length by 49-62%, while bimataprost only increased eyelash length by 38% (see Table 1 for details). Independent ocular safety studies have shown that the active agent of the invention has no effect on intraocular pressure and is therefore safe for contact lens wearers and persons with sensitive eyes. Bimataprost, used in eye drops, reduces intraocular pressure in glaucoma patients.

[0085]Same as in Example 1, the control group described in Table 1 refers to the upper right eyelashes (N=34) of all testers who use solution A; the placebo group refers t...

Embodiment 3

[0089] The active agent of the invention (i.e. (z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2 -((R,E)-3-Hydroxy-4-phenoxy-but-1-enyl)-cyclopentyl)-hept-5-enoic acid acetamide). After 8 weeks of daily use, preliminary test data showed an average increase of about 20% in the transition from villous hair to terminal hair in 10 subjects, and subjectively reported visually visible localized hair growth.

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PUM

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Abstract

Effective enhancement of eyelash length and density can be obtained by topical applications of an active agent selected from a class of compounds consisting of synthetic prostaglandin agonists, polymers thereof and mixtures thereof preferably having the chemical formula of C24H35NO5, such as 7-[3.5-dihydroxy-2-(3-hydroxy-4phenoxy-but-1-enyl)-cyclopentyl]-hept-5-enoic acid ethylamide. Such active agents having a molecular weight of 417.54 can be employed in concentrations from 0.00075% to 0.03% by weight in mixtures with inactive ingredients, such as gels, oils, etc. Results are obtained by daily topical applications of active agent in such liquid mixtures (tinctures) at the roots of the lashes and / or lash follicles.

Description

technical field [0001] The present invention relates to a composition and method for enhancing hair growth, especially promoting hair growth, eg increasing the length and density of hair or eyelashes. The composition can also effectively reduce and / or avoid hair loss during chemotherapy and promote hair growth when suffering from alopecia areata. Background technique [0002] The desire for longer, denser hair such as hair and eyelashes is evident from the multitude of cosmetic products such as mascara, eyelash extension products, etc. that aim to temporarily alter the appearance of the user. But most of these products only produce temporary effects that last from a few hours to a few weeks. While eyelash and hair transplants have been successful in producing longer-lasting results, the cost of the transplants is often unaffordable to the public. [0003] Recently, a new class of synthetic prostaglandin analogues has been proposed for enhancing eyelash growth, see for exam...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/81A61K8/73A61Q7/00A61K8/42
CPCA61K2800/78A61K8/42A61Q7/00A61K31/195A61P17/14
Inventor 林蕙君
Owner 林蕙君