Dihydroxyanthraquinones and their use

An alkyl and cyclic group technology, applied in the field of dihydroxyanthraquinones and their uses, can solve problems such as poor physical and chemical properties
CN101296916AInactive Publication Date: 2008-10-29SOSEI R&D LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOSEI R&D LTD
Publication Date
2008-10-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

A compound of formula (1), wherein X is H or -OCR1 and Y is H or -OCR2, provided that X and Y are not both H; and R is CH2OR9, CONR11R12, CN, tetrazole or COOR17; or a salt thereof, has therapeutic utility.
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Description

technical field

[0001] The present invention relates to dihydroxyanthraquinone derivatives and their use in treating diseases. Background technique

[0002] T lymphocytes are known to play a central role in the pathogenesis of many inflammatory and autoimmune diseases. Activation of T cells by antigen-presenting cells is the initial event that initiates the inflammatory process, which subsequently leads to the activation of other inflammatory cells and subsequent release of pro-inflammatory cytokines, chemotactic agents and matrix-degrading enzymes. These cell types are also known to be essential for the initiation and maintenance of angiogenesis through secretion of VEGF. Angiogenesis-driven diseases include, but are not limited to, cancer, age-related macular degeneration, and diabetic retinopathy.

[0003] Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous system. T cell proliferation leads to the release of pro-inflammatory cytok...

Claims

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