Supermolecule polymer micelle and preparation thereof

Abstract

The invention discloses a supramolecular polymer micelle and a preparation method thereof. The supramolecular polymer micelle is prepared by method that: base on raw materials of cyclodextrin and polycaprolactone and / or polylactic acid, host-guest inclusion complex is formed by interaction after mixing each raw material, then the supramolecular polymer micelle is obtained through dialysis, and the mass of cyclodextrin is excessive relative to that of polymer polycaprolactone and / or polylactic acid during preparation. Raw materials used by the method are green and commercialized, and the reaction condition required is mild. The method has advantages of simple procedure and trouble and effort saving, the micelle prepared has better stability and drug control release, and has higher drug inclusion rate and more durable drug release than routine micelles.

Description

A kind of supramolecular polymer micelle and preparation method thereof technical field The invention relates to a supramolecular polymer micelle and a preparation method thereof, belonging to the field of polymer chemistry. Background technique Polymer micelles have important application value in biomedicine, mainly in drug controlled release, diagnostic agent, gene transfection and so on. In the past few decades, micelles were mainly formed by the self-assembly of amphiphilic block copolymers. Due to the great challenges in the design and synthesis of amphiphilic polymers with certain application value, it is mainly reflected in the fact that some raw materials are not green, and the synthesis steps are time-consuming and laborious. Recently, a new method has been developed to form micelles through non-covalent interactions between hydrophilic host molecules and hydrophobic guest molecules. As described in the existing literature J.Wang, M.Jiang, J.Am.Chem.Soc.2006, 12...

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Problems solved by technology

However, when using this method, there are also great challenges in the design and synthesis of target host molecules and guest molecules, and it also requires multiple steps to complete, so it is time-consuming and laborious.

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