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Polymer composition having a high refractive index

A technology for polymerizing compositions and compounds, used in tissue regeneration, medical science, prostheses, etc., can solve the problems of unsatisfactory materials

Inactive Publication Date: 2008-12-03
CORONIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In terms of the combination of good mechanical properties and high refractive index, no known material is satisfactory

Method used

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  • Polymer composition having a high refractive index
  • Polymer composition having a high refractive index
  • Polymer composition having a high refractive index

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] synthesis

[0078]

[0079] (The above Mol.gew. refers to the molecular weight)

[0080] Reaction equation

[0081]

[0082] (The above Mol.gew. refers to the molecular weight)

[0083] Reagent:

[0084] Methacryloyl chloride

[0085]

[0086] Methyl magnesium chloride

[0087] Experimental part

[0088] (2-Methacrylic acid-2-phenylthio-1-phenylthiomethyl-ethyl ester)

[0089] 1,3-Diphenylthio-propan-2-ol was reacted with methylmagnesium chloride and methacrylic acid chloride in equimolar proportions (ratio 0.03618 mol, respectively).

[0090] 1,3-Diphenylthio-propan-2-ol (MW=276.42): (10 g=0.03618 mol) was dissolved in THF previously distilled over Na / K. To this solution was added 0.03618 mol of methylmagnesium chloride [Acros, 22% by weight solution in THF] (MW=74.79)=(2.71 g (corresponding to 12.32 g of a 22% by weight solution)). This solution was then slowly added to the following solution via a dropping funnel: 0.03618 mol of methacryloyl chlor...

Embodiment 2

[0092] synthesis

[0093]

[0094] (The above Mol.gew. refers to the molecular weight)

[0095] Reaction equation

[0096]

[0097] (The above Mol.gew. refers to the molecular weight)

[0098] Chemicals

[0099] Methacryloyl chloride (as above)

[0100] Experimental part

[0101] 1,3-Diphenylthio-propan-2-ol was reacted with methacryloyl chloride. Place the following reagents in a preheated container with a condenser and N 2 Inlet 250 ml three-necked spherical flask: 0.03 mol of methacryloyl chloride (3.88 g, 97%), about 60 ml of pre-distilled THF without inhibitors as solvent. 8.29 g of 1,3-diphenylthio-propan-2-ol (0.030 mol) and 2.94 g of triethylamine (0.030 mol) (99% by weight) were added to the dropping funnel. The solution from the dropping funnel was slowly dropped into the three-necked flask. No cooling was required as the reaction was not exothermic. A white precipitate (NEt 3 ) HCl. Stirring was continued at room temperature for 1.5 hours, then the...

Embodiment 3

[0108] synthesis

[0109]

[0110] (The above Mol.gew. refers to the molecular weight)

[0111] Reaction equation

[0112]

[0113] (The above Mol.gew. refers to the molecular weight)

[0114] Reagent

[0115] Acryloyl chloride

[0116]

[0117] Experimental part

[0118] using a condenser and N 2 Inlet preheated three-neck flask, 0.03 mol of acryloyl chloride (2.828 g, 96 wt %) as described above and 50-100 ml of inhibitor-free THF (pre-distilled) were placed in the flask as solvent. 8.29 g of 1,3-diphenylthiopropan-2-ol = 0.030 mol and 0.030 mol of triethylamine [99%] (4.1 ml) were placed in a dropping funnel. Allow the solution to drip slowly from the dropping funnel. No cooling was required as the reaction was not exothermic. A white precipitate (NEt 3 ) HCl. Stirring was continued for a further 1.5 hours at room temperature, then the precipitate was filtered and the THF was removed on a rotary evaporator. A yellow viscous liquid was obtained with a yie...

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Abstract

The present invention discloses use of a compostion of poylmers with high refractive index in ophthalmological devices and preparation thereof.

Description

technical field [0001] The present invention relates to the use in ophthalmology of polymeric compositions having a high refractive index and to a process for the preparation of said polymers. Background technique [0002] According to the present invention, polymeric compositions having a high refractive index are provided which are particularly suitable for use in ocular implants. In particular, intraocular lenses (IOLs), corneal implants, artificial corneas, etc. are considered ocular implants. Intraocular lenses have long been known. They are surgically implanted in the eye to replace the eye's natural lens and restore vision to patients plagued by cloudy or damaged lenses. If the natural lens is damaged, for example in an accident, and if the lens becomes clouded due to cataracts, which is a common situation, then the natural lens must be replaced. [0003] Intraocular lenses can be made of hard or soft polymers. The advantage of hard polymers is that they are mecha...

Claims

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Application Information

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IPC IPC(8): C08F220/38A61L27/14
CPCA61L27/18C08F220/38C08F220/30A61L2430/16C08F220/302C08F220/301C08L33/00
Inventor 沃尔夫冈·米勒-利尔海姆J·施托斯贝格A·拉舍夫斯基E·格尔尼兹E·温特
Owner CORONIS
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