Preparation for artesunate liquid-filling capsule for treating malaria

Abstract

The invention relates to the preparation of a chemical medicine preparation, artesunate used tfor curing malaria. The present invention has the advantages that: 1. Serving as the main drug, chemical medicine artesunate is sufficiently dispersed by water-soluble auxiliary ingredients of polyethylene glycol 400 and polyethylene glycol 600, thus being favorable for the absorption of main ingredients and improving the bioavailability of the main ingredient; 2. the preparation method is realized in a way that the main ingredient is sufficiently mixed with the auxiliary ingredients in a suitable proportion and then a suitable amount of Tween 80 is added in; the obtained mixture is put still after being equably mixed till liquid is defecated; 3. the defecated liquid is encapsulated into hollow capsules with the hydroxypropyl methylcellulose as the material; 4. the method is simple in production process, short in production cycle and the cost can be reduced by adopting the method; 5. the capsule is short in disintegration time limit, and high in invitro dissolve degree. The curative effect is improved and the detention time in stomach is shortened. Thereby the generation of the side effects such as drug resistance is decreased.

Description

Technical field: [0001] The invention belongs to a chemical medicine preparation, in particular to a chemical medicine preparation for treating malaria. Background technique: [0002] Malaria is a very old disease with rapid onset and rapid spread, making it difficult to control for a while. In the past, the incidence rate was very high in all parts of the world, especially in tropical and subtropical regions. Now malaria has been basically eliminated in many countries, but it is still a serious epidemic infectious disease in South Asia, the Middle East, Africa and Southeast Asian countries. Hundreds of thousands, if not millions, of people died from malaria. Timely and effective treatment of malaria and effective control of the spread of malaria in these countries and regions is still a top priority, and it is the duty-bound task of the governments of these countries and regions. The United Nations and the World Health Organization also pay great attention to the treatment...

AI Technical Summary

Problems solved by technology

However, injections were still used as the main dosage form in the past, and the inconvenience of use was its main disadvantage.

Oral preparations include Artesunate Tablets, the main disadvantage of which is the long disintegration time. Due to its insoluble nature, it is not easy to absorb, and the onset is slow. It is difficult to quickly reach the peak blood concentration, which greatly affects the oral bioavailability. Therefore, it also affects the curative effect. Artemisinin-based antimalarial drugs are highly competitive in the international market. At present, the focus of competition has changed from raw materials to finished drugs. Liquid-filled capsules have a short disintegration time limit, The characteristics of easy absorption have a strong advantage in the competition of finished drugs