Preparation method of artemether drop pills for treating malaria

Abstract

The invention relates to a preparation method of a chemical drug preparation for treating malaria which is artemether dropping pills. The preparation method has the advantages that: 1. compared with tablets, capsules and soft capsules of the normal-release preparations, the disintegration time limit is greatly shortened, and the onset of action is rapid; 2. water-soluble excipients are used for the full dispersing non-water-soluble main drug, thus being conductive to the absorption of the main drug and improving the oral bioavailability; 3. the dropping pills of the invention can be swallowed, carried out the sublingual administration and directly absorbed by sublingual mucosal veins, thus avoiding the first-pass effect of the stomach, rapidly achieving the peak value of the plasma-drug concentration, having rapid onset of action and improving the efficacy; 4. as the dropping pills of the invention have rapid absorption, the stagnation time in the stomach is short, and the dropping pills can further reduce the generation of drug resistance and other side effects; 5. the production process is simple, the production period is short, and the cost can be lowered; 6. the dropping pills can not only overcome the inconvenient usage of the intravenous drug delivery, but also can overcome the shortcoming of low bioavailability of other oral normal-release preparations.

Description

Technical field: [0001] The invention belongs to a chemical medicine preparation, in particular to a chemical medicine preparation for treating malaria. Background technique: [0002] Malaria is a very old disease with rapid onset and rapid spread, making it difficult to control for a while. In the past, the incidence rate was very high in all parts of the world, especially in tropical and subtropical regions. Now malaria has been basically eliminated in many countries, but it is still a serious epidemic infectious disease in South Asia, the Middle East, Africa and Southeast Asian countries. Hundreds of thousands, if not millions, of people died from malaria. Timely and effective treatment of malaria and effective control of the spread of malaria in these countries and regions is still a top priority, and it is the duty-bound task of the governments of these countries and regions. The United Nations and the World Health Organization also pay great attention to the treatment...

AI Technical Summary

Problems solved by technology

However, injections were still used as the main dosage form in the past, and the inconvenience of use was its main disadvantage.

Oral preparations include artemether tablets, artemether capsules, and artemether soft capsules (capsules). The peak value of blood drug concentration greatly affects the oral bioavailability, and thus also affects the competition of curative effect. The competition of artemisinin antimalarial drugs in the international market is very fierce. At present, the focus of competition has changed from raw materials to Transformed into finished medicine, the characteristics of drop pills have a strong advantage in the competition of finished medicine