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Method for synthesizing ivermectin from avermectin

A technology of avermectin and ivermectin, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as increased production costs, achieve cost savings, reduce production costs, and save catalysts The effect of dosage

Inactive Publication Date: 2009-01-07
SHIJIAZHUANG GUODA INDAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The price of catalysts in the current market continues to rise, resulting in a significant increase in production costs, and there are no other processes and catalysts to replace them. Therefore, reducing the amount of catalysts has become a top priority for manufacturers

Method used

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  • Method for synthesizing ivermectin from avermectin

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Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Embodiments (one)~(six) all carry out according to the following steps:

[0026] ①Heating and dissolving: Add the corresponding amount of solvent and abamectin into the stainless steel reaction kettle for heating to completely dissolve the abamectin. The reaction kettle is equipped with a thermometer and stirred with a glass or Teflon rod.

[0027] ②Washing: Add sodium hydroxide solution into the reaction kettle, stir and keep warm.

[0028] ③Extraction: The sodium hydroxide is removed by extraction, and the remaining substances are put into the concentration tank.

[0029] ④ Concentration: Concentrate the remaining substances in the concentration tank to remove the solvent.

[0030] ⑤ Drying: Dry the concentrated substance in the concentration tank under vacuum.

[0031] The relevant parameters of each embodiment are as follows:

[0032]

[0033] After the above steps, the pretreated abamectin is obtained, which is used as a raw material for the subsequent synth...

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PUM

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Abstract

The invention discloses a method for synthesizing ivermectin from avermectin, which belongs to the field of biological pharmacy. The method for synthesizing ivermectin is characterized in that the avermectin preprocessing step is added before synthesizing ivermectin; and the avermectin preprocessing method is carried out according to the following steps: dissolving avermectin by heating, washing with sodium hydroxide, extracting, concentrating and drying to remove impurities in avermectin. Accordingly, the use amount of a catalyst in the subsequent synthesis process can be effectively reduced to reduce the production cost. The preprocessed avermectin used for synthesizing ivermectin as the raw material can reduce the use amount of the catalyst by 50%, which can reduce the cost of the entire production process by about 15%.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and relates to a method for synthesizing ivermectin, in particular to a pretreatment method for raw materials for synthesizing ivermectin with avermectin. Background technique [0002] Ivermectin is a new type of broad-spectrum, high-efficiency, and low-toxicity antibiotic antiparasitic drug, which has a good killing effect on internal and external parasites, especially nematodes and arthropods. At present, the process of synthesizing ivermectin (Ivermectin) in the pharmaceutical industry is all formed by hydrogenation of avermectin under the effect of Wilson catalyst. The raw material avermectin used is a kind of biological product obtained from the fermentation process. The raw material itself has impurities, mainly esters, and these impurities will destroy the activity of the catalyst in the catalytic synthesis process. Therefore, in actual production, manufacturers must increase the amount ...

Claims

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Application Information

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IPC IPC(8): C07H17/08C07H1/00
Inventor 靳云峰马维宏
Owner SHIJIAZHUANG GUODA INDAL