Synthetic method of nisoldipine photolytic product reference substance

Abstract

A synthesis method of a control for the photolytic product of nisoldipine relates to the field of drug production. The method comprises the following steps that: 1) an absolute ethanol saturated solution of nisoldipine is irradiated with light in a closed container at room temperature, until the color turns from yellow to aquamarine blue and then keeps stable; 2) the obtained solution is refluxed in water bath for 20 to 40 minutes at 70 to 80DEG C, followed by the elimination of insoluble substances under the heat; 3) the obtained is dried at 50 to 70 DEG C and; 4) the obtained remnant are re-crystallized for 2 or 3 times to obtain the refined product, which appears to be a powder in pale aquamarine blue. The invention has the advantages of easy operation, no requirement of toxic reagents, minor toxic effects on human body, and minor pollution on environment.

Description

technical field

[0001] The invention relates to the field of pharmacy, in particular to a method for synthesizing a nisoldipine photolysis product reference substance. Background technique

[0002] Nisoldipine (I) is a dihydropyridine calcium antagonist, which can prevent the intake of calcium ions by cardiac muscle and vascular smooth muscle, has the effect of selectively expanding coronary arteries and peripheral blood vessels, improves myocardial blood supply, and reduces peripheral resistance, thereby Reduce myocardial oxygen consumption, enhance myocardial tolerance to hypoxia, and lower blood pressure in hypertensive patients. The drug has curative effect on coronary heart disease, hypertension and chronic congestive heart failure. Clinical studies have shown that the drug has no significant effect on the respiratory and central nervous system while causing a drop in blood pressure. Long-term treatment does not produce tolerance. The drug was pioneered by the German...

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