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2-cyano-3-(substituted) amidine-3-phenyl acrylates compounds, preparation method and use thereof

A technology of phenyl acrylates and compounds, applied in the preparation of organic compounds, botany equipment and methods, chemical instruments and methods, etc.

Inactive Publication Date: 2009-03-11
JIANGSU FLAG CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent reports for the first time that this type of compound has bactericidal activity, but the general formula of this patent does not include the compound of the general formula in which X and Y are hydrogen atoms in the compound I of the present patent application

Method used

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  • 2-cyano-3-(substituted) amidine-3-phenyl acrylates compounds, preparation method and use thereof
  • 2-cyano-3-(substituted) amidine-3-phenyl acrylates compounds, preparation method and use thereof
  • 2-cyano-3-(substituted) amidine-3-phenyl acrylates compounds, preparation method and use thereof

Examples

Experimental program
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Synthetic example

[0066] Synthetic example: 1 Compound No 1 Preparation of 2-cyano-3-(substituted) amino-3-amino-3-phenylacrylate n-propyl: (a) 2-cyano-3-hydroxyl-3-benzene The preparation method of n-propyl propionate

[0067] a-1: Preparation method 1 of n-propyl 2-cyano-3-hydroxy-3-phenylpropionate:

[0068] 24.3 grams of magnesium (1.0 moles) was placed in a 2-liter three-necked flask containing 500 milliliters of absolute ethanol and 500 milliliters of ethylene glycol dimethyl ether and 2 grams of carbon tetrabromide, stirred and reacted for 12 hours at 90° C., and depressurized After distilling ethanol and ethylene glycol dimethyl ether, add 500 milliliters of ethylene glycol dimethyl ether, stir and add 127 grams of n-propyl cyanoacetate (1.0 mole) dropwise below 20 ° C, the solution is cooled to 0 ° C, dropwise Add 140.5 g of benzoyl chloride (1.0 mol), and after the drop, the reaction solution was stirred and reacted at room temperature for 15 hours. The organic layer was washed with...

Embodiment 1

[0085] Formulation example 1: 10% EC

[0086] Compound No.1 10 parts

[0087] Tween 80 12 servings

[0088] N,N-Dimethylformamide 3 parts

[0089] Xylene make up 100 parts

Embodiment 2

[0090] Formulation Example 2: 90% Soluble Liquid

[0091] Compound No.1 90 parts

[0092] 10 parts of N-methylpyrrolidone

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Abstract

The invention discloses a 2-cyano-3-(substituted) amino-3-phenyl-acrylic acid ester compound, a preparation method and application thereof. The compound has a formula (I) structure and good fungicidal activity, can be used to prevent and treat diseases caused by a plurality of fungi such as fusarium, rust fungi, botrytis cinerea and so on. The compound has the advantages of simple process method, good sterilization effect, and broad market prospect.

Description

technical field [0001] The invention relates to the field of agricultural fungicides, in particular to a 2-cyano-3-(substituted) amino-3-phenylacrylate compound, a composition, a preparation method thereof and an application in crop fungicides. Background technique [0002] 2-Cyanoacrylate compounds were first seen in the French patent in 1969, but it was not until 1981 that the hill reaction inhibitory activity of compound 1 was reported for the first time, such compounds aroused great interest and were synthesized , activity and mode of action were thoroughly studied. And many 2-cyano-3-(substituted)amino-3-substituted phenylacrylic acid and their derivatives have 3-substituted amine group such as compound IV, compound V and compound VI. However, the structures of such compounds are different from those of the present invention. [0003] Compound IV Compound V [0004] Compound VI [0005] European Patent EP885.45 reports that certain other compounds such ...

Claims

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Application Information

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IPC IPC(8): C07C255/42C07D307/12C07D207/08C07D213/53C07D277/28A01N37/46A01N43/06A01N43/36A01N43/40A01N43/78A01P3/00
CPCC07C255/42A01N43/36A01N37/44A01N43/08A01N43/78C07D277/32C07D207/09C07D307/12A01N43/40C07C2101/14C07C2101/02C07D213/61C07C2601/02C07C2601/14
Inventor 王凤云李刚沈菲王耀良贺鹰
Owner JIANGSU FLAG CHEM IND
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