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Microrna expression abnormalities in pancreatic endocrine and acinar tumors

A technology for pancreas and pancreatic cancer, applied in antitumor drugs, medical preparations containing active ingredients, analytical materials, etc., can solve problems such as unpredictability and huge differences in malignant potential.

Inactive Publication Date: 2009-03-11
THE OHIO STATE UNIV RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Malignant potential varies widely between PETs and cannot be predicted on the basis of histologic morphology

Method used

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  • Microrna expression abnormalities in pancreatic endocrine and acinar tumors
  • Microrna expression abnormalities in pancreatic endocrine and acinar tumors
  • Microrna expression abnormalities in pancreatic endocrine and acinar tumors

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Experimental program
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Embodiment

[0206] Materials and methods

[0207] Patient data, tumor cell enrichment and RNA extraction.

[0208] Table 2 reports the clinicopathological characteristics of 40 PET and 4 PACC obtained from the frozen tissue bank of the Department of Pathology of the University of Verona, Italy. All tumors are sporadic, which is judged by the personal and family history of the patient's direct interview. PET is diagnosed by histopathology and cell marker analysis, and classified according to WHO standards (Kloppel, G. et al., "The Gastroenteropancreatic Neuroendocrine Cell System and Its Tumors: The WHO Classification." Ann. NYAcad. Set 1014: 13-27 ( 2004)). They included 28 non-functional and 12 functional tumors. The 28 NF-PET includes 11 well-differentiated endocrine tumors (WDET) and 18 well-differentiated endocrine carcinomas (WDEC). Twelve F-PETs are insulinomas, which include 11 WDET and 1 WDEC. According to WHO standards that consider tumor size, Ki-67 proliferation index, and vascular...

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Abstract

The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent.

Description

[0001] Inventors: Carlo M. Croce and George A. Calin [0002] Government funding [0003] The present invention was funded in whole or in part by project funds P01CA76259 and P01CA81534 from the National Cancer Institute. The government has certain rights in the invention. Background of the invention [0004] Pancreatic cancer can be classified according to where the cancer is found in the pancreas or according to the cell type from which the cancer originated. Pancreatic cancer can occur in the head, body, or tail of the pancreas, and the symptoms can vary with the location of the tumor in the pancreas. 70-80% of pancreatic cancers occur in the head of the pancreas. Most pancreatic cancers are of the exocrine type, and more than 90% of these exocrine pancreatic cancers are adenocarcinomas. They are almost all ductal adenocarcinomas, where the cancer occurs in the cells lining the ducts of the pancreas. In addition, there are more rare types of exocrine pancreatic cancer, such as c...

Claims

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Application Information

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IPC IPC(8): A61K38/00C12Q1/58
CPCC12Q2600/178G01N33/57438C12Q1/6886A61N1/30C12Q2600/158C12Q2600/106A61P35/00A61P35/04
Inventor C·M·克罗斯G·A·卡林
Owner THE OHIO STATE UNIV RES FOUND
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