Pharmaceutical composition containing acarbose

A technology of acarbose and composition, which is applied in the field of pharmaceutical composition containing acarbose, and can solve the problems such as the inconvenience of taking ordinary tablets

Active Publication Date: 2009-04-22
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the technical problem that the existing common tablets are inconvenient to take, and provides a pharmaceutical composition containing acarbose, which can be industrially made into orally disintegrating tablets of acarbose

Method used

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  • Pharmaceutical composition containing acarbose
  • Pharmaceutical composition containing acarbose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Acarbose: 50g

[0062] Microcrystalline Cellulose: 130g

[0063] Mannitol: 67g

[0064] Crospovidone: 33g

[0065] Citric acid: 17g

[0066] Sodium bicarbonate: 12g

[0067] Micropowder silica gel: 3.3g

[0068] Magnesium Stearate: 1.7g

[0069] Weighed according to the prescription, each material was passed through an 80-mesh sieve in advance, mixed well, and directly compressed into 1000 tablets.

Embodiment 2

[0071] Acarbose: 50g

[0072] Microcrystalline Cellulose: 180g

[0073] Mannitol: 67g

[0074] Copovidone: 5g

[0075] Crospovidone: 33g

[0076] Citric acid: 17g

[0077] Sodium bicarbonate: 12g

[0078] Micropowder silica gel: 3.3g

[0079] Magnesium Stearate: 1.7g

[0080] Weighed according to the prescription, each material was passed through an 80-mesh sieve in advance, mixed well, and directly compressed into 1000 tablets.

Embodiment 3

[0082] Acarbose: 50g

[0083] Microcrystalline cellulose: 90g

[0084] Mannitol: 67g

[0085] Crospovidone: 33g

[0086] Citric acid: 17g

[0087] Sodium bicarbonate: 12g

[0088] Micropowder silica gel: 3.3g

[0089] Magnesium Stearate: 1.7g

[0090] Weighed according to the prescription, each material was passed through an 80-mesh sieve in advance, mixed well, and directly compressed into 1000 tablets.

[0091] The embodiment is verified, and the results are shown in the following table:

[0092]

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Abstract

The invention relates to a medicine composition containing acarbose. The composition can be made into orally disintegrated ablets through screening each minor ingredient and dosage thereof. Therefore, the invention overcomes the defect of inconvenient taken existing in the prior tablet and capsule, and provides an acarbose preparation which can be disintegrated quickly in oral cavity, and can be taken more easily without water.

Description

technical field [0001] The present invention belongs to the field of pharmaceutical preparations, and more particularly relates to a pharmaceutical composition containing acarbose. Background technique [0002] Acarbose, chemical name: O-4,6-dideoxy-4-[(1S,4R,5S,6S)4,5,6-trihydroxy-3-(hydroxymethyl)-2 -Cyclohexenyl-1-amino]-a-D-glucopyranosyl-(14)-O-a-D-glucopyranosyl-(14)-D-glucopyranosyl. It is a new type of oral hypoglycemic drug, which is an α-glucosidase inhibitor. The results of clinical studies have proved that acarbose is a safe and effective drug for controlling carbohydrate metabolism. Can effectively reduce postprandial blood sugar, fasting blood sugar and glycosylated hemoglobin values. [0003] The currently clinically used dosage forms are ordinary tablets and capsules, and the tablets are taken by chewing before meals or with the first few mouthfuls of food. For elderly patients and patients who are inconvenient to take medicines on the go, tablets and caps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61K9/20A61K47/10A61K47/12A61K47/38A61P3/10
Inventor 卢良华
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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