Bletilla striata polysaccharide, preparation method and new uses thereof

A polysaccharide and pore-type technology, which is applied in the preparation of Baiji polysaccharides. Baiji polysaccharides can solve the problems of incomplete removal of impurities, waste of drug residues, and many impurities in polysaccharides in the field of preparation of drugs for the treatment of gastric ulcer and silicosis, and achieve the goal of containing impurities. Less, save production cost, high purity effect

Active Publication Date: 2009-05-13
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The second object of the present invention is to solve the incomplete impurity removal in the water extraction and alcohol precipitation method for the preparation of polysaccharides in the prior art. The obtained polysaccharide has more impurities and poor color, which is not conducive to the further purification of polysaccharides. Defects with lower content, and provide a simpler and easier extraction method,

Method used

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  • Bletilla striata polysaccharide, preparation method and new uses thereof
  • Bletilla striata polysaccharide, preparation method and new uses thereof
  • Bletilla striata polysaccharide, preparation method and new uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Embodiment 1 The white and polysaccharides of the present invention are obtained by the following extraction and purification methods:

[0099] (1) Take the tuber of Baiji raw medicinal material, crush it into coarse powder, take 5 kg of coarse powder (ie raw material 1), cold soak or reflux extraction with 10 times the weight of the coarse powder in 95% ethanol or reflux for 2 times, and dry the dregs after extraction until no alcohol smell;

[0100] (2) Dry the above-mentioned medicinal residues until they have no alcohol smell, then use 10 times the weight of the medicinal residues to leach for 3 hours at a temperature of 60° C., extract 3 times, combine the extracts, and filter;

[0101] (3) the above-mentioned filtrate is passed through macroporous type weakly basic anion resin and macroporous type weakly acidic cation resin mixed resin column, eluting with deionized water, and collecting eluate;

[0102] (4) Concentrate the above eluent to a relative density of 1...

Embodiment 2-6

[0108] Examples 2-6 are also whitening and polysaccharide products of the present invention, and the method for obtaining them is the same as that of Example 1 except for the distinguishing measures listed in Table 1.

[0109] The used macroporous type weakly basic anion resin model of above-mentioned embodiment is D280, and the macroporous type weakly acidic cationic resin model is D113; The gel type weakly basic anion resin model is 330, and the gel type weakly basic anion resin model is 312, gel-type weakly acidic cationic resin model is 110.

[0110] Table 1 The present invention of embodiment 1-6 and the difference measure that polysaccharide product obtains

[0111]

[0112] Table 2 Examples 1-6 of the present invention whitening and polysaccharide content and conventional physical properties

[0113]

[0114] Table 1 shows that: the content of white and polysaccharide in white and polysaccharide of the present invention is relatively high, and its content is 70%~...

Embodiment 7

[0115] Embodiment 7 The preparation method of Baiji polysaccharide of the present invention (following tests all do three repetitions, test result is the average value of three repetitions)

[0116] The preparation method of whitening and polysaccharide of the present invention, carry out according to the following steps:

[0117] (1) Take the tuber of Baiji raw medicinal material, crush it into coarse powder, take 5 kg of coarse powder (ie raw material 1), cold soak or reflux extraction with 10 times the weight of the coarse powder in 95% ethanol or reflux for 2 times, and dry the dregs after extraction until no alcohol smell;

[0118] (2) Dry the above-mentioned medicinal residues until they have no alcohol smell, then use 10 times the weight of the medicinal residues to leach for 3 hours at a temperature of 60° C., extract 3 times, combine the extracts, and filter;

[0119] (3) the above-mentioned filtrate is passed through macroporous type weakly basic anion resin and mac...

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Abstract

The invention discloses bletilla polysaccharide, a preparation method and novel application thereof. The bletilla polysaccharide is prepared by the following method: firstly, coarse bletilla powder is taken as a raw material, and is extracted by alcohol; secondly, herb residue is extracted by water; thirdly, resin is used for removing proteins of a concentrated solution; and fourthly, after an eluent is condensed, the bletilla polysaccharide is precipitated by the ethanol. The content of the bletilla polysaccharide prepared by the method is high, reaches 70 to 74 percent, and is improved by 14 to 20 percent compared with the prior technical method, and the bletilla polysaccharide has good protein removal effect. The preparation method can also utilize the herb residue produced in the process of production of bletilla particle medicines as the raw material, so as to save the production cost. The invention also provides the novel application of the bletilla polysaccharide to preparation of medicines for treating gastric ulcer and medicines for treating silicosis and a commonly used medical preparation formulation.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the preparation of a polysaccharide from Baiji and the new application of the polysaccharide from Baiji to the preparation of medicines for treating gastric ulcer and silicosis. Background technique [0002] Bletilla striata is the dry tuber of orchid plant Bletilla striata. A heteropolysaccharide obtained by water extraction and alcohol precipitation of Baiji tubers. The heteropolysaccharide is called Baiji gum, and Baiji gum is also called Baiji polysaccharide, Baiji mannan. [0003] Baiji (that is, Baiji tuber) has the effects of astringent and hemostasis, clearing away heat and promoting dampness, reducing swelling and promoting granulation. It is widely used clinically to treat hemoptysis, hematemesis, traumatic bleeding, sore swelling, chapped skin, tuberculosis hemoptysis, ulcer bleeding and other diseases; et al., Preparation of Baiji Microspheres and Experimental Stu...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P1/04A61P11/00
Inventor 周敏李文黄春球吕小波武正才
Owner YUNNAN PHYTOPHARML
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