Preparation of salvianic acid A sodium pure product

A technology of pure Danshensu sodium, which is applied in the field of preparation of pure Danshensu sodium, can solve the problems that it is not suitable for industrial production and the purity cannot reach 98%, and achieves low cost, low environmental pollution and high product purity. Effect

Inactive Publication Date: 2009-05-20
HARBIN PHARMA GROUP SANJING NUOJIE PRARMACEUTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The danshensu sodium prepared by these four patents has a purity of less than 98%, and some patents are not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Salvia miltiorrhiza (individual goods) 3kg, add water to cook 3 times, add 7 times of water for the first time, cook for 8 hours, add 5 times of water for the second time, cook for 4 hours each, filter, combine the filtrates for three times; concentrate to an appropriate amount, cool to At room temperature, add 95% ethanol, stir while adding, until the alcohol content of the solution is 50%; after standing at room temperature for 12 hours, filter, concentrate the filtrate to an appropriate amount, and cool to room temperature; add 95% ethanol, stir while adding, until The alcohol content of the solution is 80%. After standing at room temperature for 12 hours, filter; the filtrate is concentrated to an appropriate amount, cooled to room temperature, add 4 times the amount of water, stir while adding, place for 1-2 hours, and filter; the filtrate has large pores Adsorption resin column (AB-8, 800g), eluting with water, collecting eluent, polyamide column (60-100 mesh, 250g...

Embodiment 2

[0040] Salvia miltiorrhiza (individual goods) 3kg, add water to cook 3 times, add 7 times of water for the first time, cook for 8 hours, add 5 times of water for the second time, cook for 4 hours each, filter, combine the filtrates for three times; concentrate to an appropriate amount, cool to At room temperature, add 95% ethanol, stir while adding, until the alcohol content of the solution is 50%; after standing at room temperature for 12 hours, filter, concentrate the filtrate to an appropriate amount, and cool to room temperature; add 95% ethanol, stir while adding, until The alcohol content of the solution is 80%. After standing at room temperature for 12 hours, filter; the filtrate is concentrated to an appropriate amount, cooled to room temperature, add 4 times the amount of water, stir while adding, place for 1-2 hours, and filter; the filtrate has large pores Adsorption resin column (AB-8, 800g), elute with water, collect the eluate; concentrate the eluate to an appropr...

Embodiment 3

[0042] Salvia miltiorrhiza (decoction piece) 3kg, add water to boil 3 times, add 6 times the amount of water for the first time, boil for 6 hours, add 5 times the amount of water for the second time, boil for 4 hours each, filter, combine the filtrates for three times; concentrate to an appropriate amount, and cool to room temperature , add 95% ethanol, stir while adding, until the alcohol content of the solution is 40%; after standing at room temperature for 12 hours, filter, concentrate the filtrate to an appropriate amount, and cool to room temperature; add 95% ethanol, stir while adding, to the solution The alcohol content is 70%, after standing at room temperature for 12 hours, filter; the filtrate is concentrated to an appropriate amount, cooled to room temperature, add 3 times the amount of water, stir while adding, place for 1-2 hours, and filter; the filtrate is adsorbed by macropores Resin column (D101, 800g), elute with water, collect the eluate, put the eluate on a ...

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PUM

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Abstract

The invention discloses a preparation method of a pure product of Salvianic acid A sodium, which comprises processing steps: 1. salvia miltiorrhizae is extracted by a hydrothermal method, and an extracting solution is condensed, deposited in alcohol and filtered; 2. a filtrate is condensed, deposited in alcohol and filtered; 3. the filtrate is condensed, added with water and filtered, and the filtrate is put into a macroporous absorption resin column and washed by water; 4. after a water lotion is condensed, the step is carried out in accordance with step (5); or the water lotion is put into a polyamide column and washed by water, and after the water lotion is condensed, the step is carried out according to step (5); 5. the water lotion after condensation is mixed with silicon gel, dried, column-packed and eluted by an organic solvent, and then an eluent is collected, recovered to be dry to obtain dry paste; and 6. the dry paste is taken and dissolved by the organic solvent, and PH value is adjusted, and then the material is stood and crystallized; or the dry paste is taken and dissolved by a solvent, and then put into a Sephadex LH-20 column or reversed-phase silica gel column. The PH value is adjusted by the eluent, and standing and crystallizing are carried out. The Salvianic acid A sodium prepared by the method has purity of more than or equal to 98 percent (standardized by NICPBP in respect of standard substances). Furthermore, the method has low cost, less pollution to environment and easily industrialized production.

Description

technical field [0001] The invention relates to a preparation method for extracting, separating and refining danshensu sodium from traditional Chinese medicine salvia miltiorrhiza. Background technique [0002] Salvia miltiorrhiza is a commonly used traditional Chinese medicine, first recorded in "Shen Nong's Materia Medica", listed as top grade. Chinese Pharmacopoeia (2005 Edition) stipulates that Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge. [0003] Danshensu is one of the water-soluble active ingredients in Danshen, which has various pharmacological effects [You Jingke, Zi Rongbing, Jiang Ronghai, Zhonghua Practical Medicine, 2002; 4(23)]. ① Anti-atherosclerosis, ② Protect liver cells, ③ Anti-inflammation and enhance body immunity, ④ Protect the heart, ⑤ Improve microcirculation and anticoagulation, ⑥ Dilate coronary arteries, ⑦ Inhibit platelet aggregation, ⑧ Resistance to hypoxia. [0004] At present, there are four main patents for the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/52C07C51/42A61K36/53
Inventor 魏峰
Owner HARBIN PHARMA GROUP SANJING NUOJIE PRARMACEUTICAL
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