Sleep inducer and stress insomnia ameliorating agent

A technology for sleep induction and oral administration, which is applied in the field of sleep inducers and stress insomnia improvers, and can solve problems such as side effects and drug dependence restrictions

Inactive Publication Date: 2009-05-20
FUAN KERU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the effect of improving insomnia symptoms is largely limited by the emotional state of the subject and the surrounding environment. In addition to the characteristics of the point of action of the drug used, it is often limited by reasons such as side effects and drug dependence.

Method used

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  • Sleep inducer and stress insomnia ameliorating agent
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  • Sleep inducer and stress insomnia ameliorating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0060] The following examples are given to describe the present invention in detail, but the present invention is not limited to these examples.

[0061] [Test condition 1]

[0062] Test condition 1 is applicable to Examples 1 to 4, and experiments are carried out in each example by changing the time and compound.

[0063] Experimental animals: Breeding roosters (Julia, 5 or 6 days old) were used in the experiment. Before the samples were given, the experimental animals were divided into groups according to body weight, 6 to 10 as a group.

[0064] Breeding conditions: Under the condition of 30±1° C., commercially available feed (manufactured by Toyohashi Feed Co., Ltd., AX) and water were freely ingested.

[0065] Test samples: the following reagents were respectively dissolved in 0.85% normal saline containing 0.1% Evans blue (if necessary, 5% DMSO was used to aid dissolution) for preparation.

[0066] The reagent that embodiment uses:

[0067] (1) L-serine (manufactured ...

Embodiment 1

[0093] Example 1 used the following compounds as test samples. Pattern classification of chick behavior. The measurement results (number of seconds) are shown in Table 1. In addition, sleep behavior such as figure 1 shown.

[0094] (1) Control group (10 rats),

[0095] (2) L-serine [L-Serine (L-Ser)] 0.21 μmol administration group (8 rats),

[0096] (3) L-serine [L-Serine (L-Ser)] 0.42μmol administration group (7 rats),

[0097] (4) L-serine [L-Serine (L-Ser)] 0.82 μmol administration group (7 rats).

[0098] as table 1, figure 1 As shown, in the L-serine 0.84 μmol-administered group, a significant sleep-inducing effect and stress-induced insomnia-improving effect were shown compared with the control group.

[0099] Table 1

[0100] Table 1: Statistical results of behavioral observations of groups administered with various concentrations of L-serine (L-Ser)

[0101] L-Ser (μmol) control 0.21 0.42 0.84 spontaneous movement 410±72 367±74 314±84 1...

Embodiment 2

[0104] Example 2 used the following compounds as test samples. The behavior of chick is carried out pattern classification, measurement result (number of seconds) is as shown in table 2, in addition, sleep behavior is as follows figure 2 shown.

[0105] (1) Control group (7 rats),

[0106] (2) L-serine [L-Serine (L-Ser)] 0.82μmol administration group (7 rats),

[0107] (3) D-serine [D-Serine (D-Ser)] 0.82 μmol administration group (7 rats).

[0108] As in Table 2, figure 2 As shown, compared with the control group, the L-serine administration group was almost the same as Example 1, and both showed significant sleep-inducing effects and stress-induced insomnia-improving effects.

[0109] In addition, in order to confirm the sleep-inducing effect and stress-induced insomnia-improving effect of other compounds having a structural unit of L-serine (Serine Unit), the following examples were performed.

[0110] Table 2

[0111] Table 2: Behavioral Observation Statistical Res...

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Abstract

The object is to develop a sleep-inducing agent and an ameliorating agent for stress-induced insomnia. Disclosed is a sleep-inducing oral preparation comprising one or more members selected from serine, phosphoserine, phosphatidylserine, lysophosphatidylserine, acetylserine (which are compounds having a serine unit) and cysteine each in an L-form.

Description

technical field [0001] The present invention relates to a sleep inducing agent and an agent for improving stress insomnia. Background technique [0002] Sleep is an important physiological function of animals with developed brains and an indispensable activity for survival. If you don't get enough sleep, it can have a negative impact on your brain's ability to process information. Therefore, the more advanced animals with well-developed brains, the greater the role of sleep. It is precisely because of good quality sleep that the brain's advanced information processing capabilities can be brought into play. [0003] In recent years, the degree of concern for sleep has become higher and higher than ever before. There are two reasons for this. The first is that with the advancement of brain science, people gradually realize the importance of sleep. The other is that modern society has changed. The active state that sacrifices sleep for chronicity produces all sorts of advers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/661A61P25/20
CPCA61K31/661A61K31/198A61P25/00A61P25/20A61K31/195A61K31/685
Inventor 韩力速水耕介古瀬充宏
Owner FUAN KERU
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