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Catheter lock solution comprising citrate and paraben

A technology of hydroxybenzoate and methyl hydroxybenzoate is applied in the field of tube-sealing solutions containing citrate and paraben, and can solve the problems of reducing citrate and reducing antimicrobial effect, etc.

Active Publication Date: 2009-05-27
ZUREX PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, lowering the concentration of citrate resulted in a lower antimicrobial effect

Method used

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  • Catheter lock solution comprising citrate and paraben
  • Catheter lock solution comprising citrate and paraben
  • Catheter lock solution comprising citrate and paraben

Examples

Experimental program
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Embodiment 1

[0079] A lock solution was prepared according to the present invention to include citrate (provided as trisodium citrate) at a concentration of 7% by weight, methylparaben at a concentration of 0.18% by weight, and propylparaben at a concentration of 0.02% by weight. The target pH of the lock solution was 4.5, and the actual pH measured during the test was 4.58. The solution was contacted with various bacterial colonies by injecting bacterial spores into the prepared solution, and the bacteria were scored periodically (60 min, 24 h, 48 h, and 72 h) to determine the number of colony forming units (CFU) per mL. number. The data are shown in Table I below:

[0080] Table I

[0081]

Embodiment 2

[0083] A lock solution was prepared according to the present invention to include citrate (provided as trisodium citrate) at a concentration of 7% by weight, methylparaben at a concentration of 0.18% by weight, and propylparaben at a concentration of 0.02% by weight. The target pH of the lock solution was 6.2, and the actual pH measured during the test was 6.26. The solution was contacted with various bacterial colonies by injecting bacterial spores into the prepared solution, and the bacteria were scored periodically (60 min, 24 h, 48 h, and 72 h) to determine the number of colony forming units (CFU) per mL. number. The data are shown in Table 1I below:

[0084] Table II

[0085]

Embodiment 4

[0093] comparative example

[0094] A lock solution of saline only (0.85%) was prepared. The saline solution was contacted with various bacterial colonies by injecting bacterial spores into the prepared solution, and the bacteria were scored periodically (60 minutes, 24 hours, 48 ​​hours and 72 hours) to determine colony forming units per milliliter ( CFU) number. Data are shown in Table 1V below:

[0095] Table IV

[0096]

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Abstract

This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.

Description

technical field [0001] The present invention relates generally to catheters, such as intravascular catheters and other body cavity catheters, and methods of preventing blockage and infection of such catheters. More particularly, but not exclusively, the present invention relates to the infusion of lock solutions into indwelling catheters, such as indwelling intravascular catheters, for inhibiting obstruction and infection in animals with indwelling catheters. Background technique [0002] By way of background, catheters are being used with increasing frequency to treat patients requiring multiple medical procedures. Catheters can provide many benefits to patients; for example, catheters provide easy access to the patient's vasculature for the infusion of fluids such as drugs, nutrients, electrolytes, or fluids used in chemotherapy, or for withdrawing blood on an intermittent basis without having to Repeat the injection. Catheters are used to infuse large volumes of fluids ...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61K31/54A01N37/10A01N37/00A61M31/00
CPCA61L2300/404A61L29/14A61M25/0017A61L29/16A61L2300/42A01N37/04A01N37/10A61P31/00A61P31/04A61P7/02A61P7/08A61K31/194A61K31/5415A61K47/10A61K47/34
Inventor 斯蒂芬·阿什雅努什·什泰察克加里·L·斯万松
Owner ZUREX PHARMA