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Open type atomizing field desorption ionization method and apparatus thereof

An ionization and open technology, applied in the field of mass spectrometry instruments, can solve the problems of large influence on ionization efficiency, lack of ion focusing function, and ionization efficiency to be improved, etc., to achieve ion focusing, improve ionization effect, power supply The effect of low voltage requirements

Active Publication Date: 2009-06-24
TSINGHUA UNIV +1
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Problems solved by technology

[0012] The desorption electrospray ionization device (DESI) realizes the open structure design, but the main problems are: ① The ionization efficiency needs to be improved, and the sample properties have a great influence on the ionization efficiency
② The ion transmission system needs to be improved, and does not have the ion focusing function

Method used

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  • Open type atomizing field desorption ionization method and apparatus thereof
  • Open type atomizing field desorption ionization method and apparatus thereof
  • Open type atomizing field desorption ionization method and apparatus thereof

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Embodiment Construction

[0034] Concrete structure, principle and working process of the present invention are further described below in conjunction with accompanying drawing:

[0035] figure 1 is a schematic diagram of the open spray field desorption ionization method.

[0036] The ionization process is as follows:

[0037] 1) The auxiliary liquid containing the sample is sprayed to form spray droplets 7 containing the sample in an open environment and without the action of an electric field, which can be sprayed by auxiliary gas or other methods;

[0038] 2) In an open environment, the spray droplet 7 containing the sample enters the ionization electric field 11; under the action of the electric field, the spray droplet is polarized to form a charged droplet 8, and the charged droplet is ionized Under the action of the electric field, it moves toward the collection cone 5 to form sample ions.

[0039] figure 2 is a schematic diagram of the open spray field desorption ionization method using a ...

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Abstract

The invention provides an open type spray field desorption and ionization method and an ionization device. The process of ionization comprises the following steps: a sample-containing assistant solution forms sample-containing spray drops in an open environment without the action of an electric field, or a sample is attached to an object carrier, and spray drops free of the sample absorb the sample on the object carrier and form a sample-containing spray; the two sample-containing spray drops enter an extra ionized electric field; and the sample is ionized under the action of the electric field. Due to the unique electrode design, the distribution of the ionized electric field has the function of ion focusing. By adopting the sample introduction method of attaching the sample to the object carrier, the sample can be analyzed in the original environment, and the analysis only requires a small amount of the sample. By adopting an independent electrode structure, the ionization device can ensure that the influence of a spray nozzle and a collection cone on the ionized electric field is reduced, so that an ion source is capable of working independently and is compatible with a common mass spectrometer.

Description

technical field [0001] The ionization (ionization) method and ionization device (ion source) involved in the present invention are applied in the field of mass spectrometry analysis, and belong to the related technology of mass spectrometry instruments used in an open environment. This ionization method can also be extended and applied to other ionization analysis fields. Background technique [0002] Traditional ionization methods can be summarized as electron bombardment ionization (EI), chemical ionization (CI), field desorption ionization (FD / FI), fast atom bombardment ionization (FAB) and so on. The traditional ionization technology requires the sample to be introduced into a high vacuum system, the device and operation are complicated, and it is easy to cause problems such as contamination of the ion source and analyzer. In addition, these ionization methods are not suitable for research fields such as life sciences due to the intense energy transfer process and the p...

Claims

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Application Information

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IPC IPC(8): G01N27/62H01J49/26G01N27/626
Inventor 再帕尔·阿不力孜唐飞贺玖明赵猛王晓浩
Owner TSINGHUA UNIV
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