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Medicament composition containing paracetamol and pseudoephedrine hydrochloride and preparation method thereof

The technology of a composition and a monohydrate, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve the problems of poor fluidity, electrostatic adsorption, and poor compressibility of acetaminophen, and achieves simplified process, Storage stability, improved flow and compressibility effects

Inactive Publication Date: 2014-07-09
北京德众万全医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a pharmaceutical composition containing anti-common cold or influenza drug paracetamol and pseudoephedrine hydrochloride and its preparation method, thereby solving the problem of poor fluidity and compressibility of paracetamol in the production process. Technical difficulties and problems caused by poor performance and electrostatic adsorption

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation:

[0023] Weigh the prescribed amount of acetaminophen and spray-dried lactose monohydrate and pulverize them in a universal grinder, grind pseudoephedrine hydrochloride with a mortar, and mix them with precrossed starch and L-HPC in equal increments, weighing Prepare polyvinylpyrrolidone as an aqueous solution as a binder to granulate, add the remaining L-HPC, add magnesium stearate, mix, and compress into tablets to obtain the product.

Embodiment 2

[0030] Preparation:

[0031] Weigh the prescribed amount of acetaminophen and spray-dried lactose monohydrate and put them together in a universal grinder to pulverize, grind pseudoephedrine hydrochloride into fine powder with a mortar, mix with crospovidone evenly, and weigh hydroxypropyl methylcellulose It is formulated into an aqueous solution as a binder for granulation, and then mixed with micro-powdered silica gel evenly, and then packed into capsules to obtain the product.

Embodiment 3

[0038] Preparation:

[0039] Weigh the prescribed amount of acetaminophen and spray-dried lactose monohydrate, put them into a universal pulverizer, and pulverize the pseudoephedrine hydrochloride with a mortar, then mix them with microcrystalline cellulose and sodium carboxymethyl starch in equal increments , weigh the starch and make it into an aqueous solution as a binder to make granules, add magnesium stearate, mix, and press into tablets to obtain.

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PUM

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Abstract

The invention discloses a stable pharmaceutical composition and method for preparing same. The composition contains acetaminophen, pseudoephedrine hydrochloride and pharmaceutically acceptable accessories capable of improving disadvantages such as bad fluidity and compressibility, and electrostatic absorption during the production of acetaminophen which is suitable for industrialized production.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing paracetamol and pseudoephedrine and a preparation method thereof. Background technique [0002] Acetaminophen and pseudoephedrine hydrochloride are common medicines for treating colds. Due to their remarkable curative effect, most of the compound preparations currently on the market for treating common cold or influenza symptoms contain these two medicines. Acetaminophen is a raw material with extremely poor fluidity and compressibility, and during the production operation, it will generate a lot of static electricity in the drug or drug container, which will bring trouble to the operation process and increase the loss of materials. Big. Usually, a variety or a large amount of auxiliary materials are added to improve the fluidity and compressibility of acetaminophen, and special equipment such as ion bars are used to eliminate electrostatic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/167A61K31/137A61P31/16A61P11/00
Inventor 吕青远
Owner 北京德众万全医药科技有限公司
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