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Medicine composition for rheumatism and its preparation

A composition and technology for rheumatism, applied in the direction of drug combination, pharmaceutical formula, drug delivery, etc., can solve the problems of high production cost, poor absorption, etc., and achieve the effect of reducing the amount of medicine taken by patients

Active Publication Date: 2013-06-05
重庆昭德堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Another object of the present invention is to develop a method for preparing a pharmaceutical composition for the treatment of rheumatism that has excellent performance and meets the standards of the Pharmacopoeia of the People's Republic of China by utilizing the nine medicinal materials in the composition as raw materials, and overcomes the prior art The shortcomings of high production cost, low bioavailability, and poor absorption improve product quality, reduce costs, and are convenient to take, better meeting medical needs and utilization of raw materials

Method used

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  • Medicine composition for rheumatism and its preparation
  • Medicine composition for rheumatism and its preparation
  • Medicine composition for rheumatism and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Using Geranium 15.9g, Millipeda 12.5g, Xugufeng 9g, Drynaria 9g, Dogji 7.9g, Gentiana 7.9g, Radix Wujiapi 3.9g, Gardenia 7.9g, Chenpi 1.5g as raw materials, take 1080g white wine for spare;

[0064] Grind each raw material into a coarse powder passing through a 40-mesh sieve, soak the coarse powder with white wine as a solvent cover for 60 hours, and then place it in a percolator to slowly carry out percolation at a percolation rate of 4ml min -1 kg -1 , collect percolate 780ml, leave standstill, filter, make medicated wine.

[0065] Concentrate the prepared medicated wine into an extract with a relative density of 1.05 (50-60°C), add 15.1 g of starch, mix well, spray dry, and pack the obtained granules into capsules to obtain capsules; control the temperature of the air intake during drying At 80°C, material temperature at 70°C, spray pressure at 0.1Mpa, infusion frequency at 10r / min.

Embodiment 2

[0067] Take 12.5g of geranium, 15.9g of Caulis Spatholobus, 6g of Xugufeng, 6g of Rhizoma Drynariae, 5.5g of Dogji, 5.5g of Gentiana officinalis, 3g of Radix Wujiapi, 5.5g of Gardenia, and 0.5g of tangerine peel, take 860g Liquor spare;

[0068] Grind each raw material into a coarse powder passing through a 40-mesh sieve, soak the coarse powder with white wine as a solvent cover for 60 hours, and then place it in a percolator to slowly carry out percolation at a percolation rate of 4ml min -1 kg -1 , collect percolate 620ml, leave standstill, filter, make medicated wine.

Embodiment 3

[0070] Use 14g of Geranium, 16g of Caulis Spatholobus, 8.5g of Xugufeng, 8.5g of Rhizoma Drynariae, 6.5g of Dogji, 7g of Gentiana, 3g of Wujiapi, 7.5g of Gardenia, and 1g of Tangerine Peel, and dissolve 100g of sucrose Reserve in 1030g white wine;

[0071] Grind each raw material medicine into a coarse powder passing through a 60-mesh sieve, soak the coarse powder with white wine as a solvent cover for 48 hours, and then place it in a percolator to slowly carry out percolation, and the percolation speed is 3ml·min -1 kg -1 , collect percolate 750ml, leave standstill, filter, make medicated wine.

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Abstract

The invention discloses a pharmaceutical composition for curing rheumatism (namely a pharmaceutical composition of compound rheumatism) and a preparation method thereof. The invention adopts nine bulk drugs including geranium wilfordii, caulis spatholobi, berba aristolochiae mollissimae, rhizoma drynariae, rhizoma cibotii, gentiana macrophylla, acanthopanax bark, gardenia and dried orange peel; the basic preparation method of the invention comprises the following steps: the bulk drugs are crushed into coarse powder capable of passing through 20-80mesh sieves; a liquor is used as the solvent to tightly cover and soak the coarse powder for 36-72h; the soaked powder is put into a percolator to be percolated with a speed of 2-4ml.min<-1>.kg<-1>, 45-1150ml of percolate is collected, kept still and filtrated and then the drug liquor is prepared; and after concentration and drying, various medicament forms that are clinically acceptable are prepared. The bulk drug mixture ratio of the pharmaceutical composition of the compound rheumatism of the invention is obtained by scientific selection. The pharmaceutical composition has the effects of relieving rheumatic pains and activating blood, relaxing muscles and strengthening bones, can be used for curing rheumatic arthralgia and myalgia as well as acroanesthesia and can realize the curing of both symptom and root diseases.

Description

technical field [0001] The invention relates to the field of a traditional Chinese medicine composition and its preparation process, more specifically to a medicinal composition for treating rheumatism and a preparation method thereof. Background technique [0002] Rheumatism and rheumatoid diseases are intractable diseases that are difficult to cure. They suffer from joint and muscle pain, numbness and deformation, especially in cloudy and rainy weather. , the condition is exacerbated, seriously affecting the health. In the prior art, massage, massage, acupuncture or some medicines for relaxing tendons and activating blood circulation are usually used. Although they play a relieving effect, the curative effect is slow, the cost is high, the symptoms are not cured, and often accompanied by toxic and side effects. [0003] Based on the shortcomings in the prior art, the present invention improves the medicine for treating rheumatic diseases and the preparation process, so th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/00A61K9/16A61K9/20A61K9/48A61P29/00
Inventor 唐德江陈犁
Owner 重庆昭德堂制药有限公司