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Microbial strain for antianaphylaxis symptom, composition thereof and method for producing interferon-gamma by using the microbial strain irritation cell

A microbial and anti-allergic technology applied in the field of isolated Lactobacillus casei

Active Publication Date: 2009-08-12
BIO RAY BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The impact of these allergic symptoms can be as short as a few weeks or as long as several months. For allergy sufferers, it is a major factor affecting the quality of life and modern society has paid a huge cost for it.

Method used

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  • Microbial strain for antianaphylaxis symptom, composition thereof and method for producing interferon-gamma by using the microbial strain irritation cell
  • Microbial strain for antianaphylaxis symptom, composition thereof and method for producing interferon-gamma by using the microbial strain irritation cell
  • Microbial strain for antianaphylaxis symptom, composition thereof and method for producing interferon-gamma by using the microbial strain irritation cell

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0046] 1. In vitro experiment

[0047] Experimental direction

[0048] In vitro experiments are mainly divided into two parts. The first part is to isolate peripheral blood mononuclear cells from blood samples of patients with allergic symptoms and co-culture them with reagents or various strains to observe the effect of peripheral blood mononuclear cells on reagents or strains. Differences in cytokine production by strains. The second part is to collect patients with different allergic symptoms, and further co-culture their peripheral blood mononuclear cells with reagents or various strains to know the ability of BRAP-01 to resist different allergic symptoms.

[0049] Strain preparation

[0050] BRAP-01 is a strain screened from infant feces samples. The strain has been identified as Lactobacillus paracasei. After the strain is activated and cultured, it is freeze-dried by freeze-drying. The number of bacteria detected by freeze-dried bacteria powder must be greater th...

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PUM

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Abstract

The invention comprises a separated microorganism strain, which is named Lactobacillus paracasei BRAP-01 and has an allergic symptom-resistance function. The invention also comprises a composition for resisting allergic symptoms, which comprises an effective quantity of the separated microorganism strain and an excipient. The invention also provides a method for stimulating cells to produce interferon-gamma, which comprises the following steps: providing cells of a mammal; and co-culturing the cells of the mammal and the allergic symptom-resistance microorganism strain subjected to heat treatment.

Description

technical field [0001] The present invention relates to an isolated Lactobacillus paracasei, and in particular to its usefulness against allergic symptoms. Background technique [0002] Allergic disease is a kind of immune disease, which is the imbalance of immune function in the human body. As the antigen (allergen) enters the human body, the body will produce immune protection. When the human body is exposed to the antigen again, it will induce the body’s immune system to respond, and T cells will release interferon (Interferon, IFN)-γ, white blood cells Interleukin (IL)-2 makes the immune response tend to the first type of T cell response, so B cells secrete more immunoglobulin G (IgG). However, for people with allergies, when the allergen enters the body, it will induce the body's immune system to move towards the second type of T cell immune response. The T cell will release interleukin 4, 5, 9, and 13, allowing immune B cells to produce immune response. Globulin E (I...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/74A61K9/19A61P37/08C12R1/225A61K35/747
Inventor 许清祥赖订颖王樱谕李欣桦薛如婷
Owner BIO RAY BIOTECH
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