Anastrozole controlled release patch and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical technology, disclosing an anastrozole controlled release patch and a preparation method thereof. The invention comprises a back lining layer, a medicine reservoir and an anti-sticking layer, wherein, the medicine reservoir comprises remedium cardinale anastrozole, pressure sensitive adhesive and sorbefacient by skin, wherein, the anastrozole accounts for 0.5-30wt%, the pressure sensitive adhesive accounts for 70-90wt% and the sorbefacient by skin accounts for 0.5-50wt%; inert filler, plasticizer, tackifier, chemical inhibitor and the like can also be added to the list. The anastrozole, the pressure sensitive adhesive and the sorbefacient by skin are fully mixed and transferred to be coated on the anti-sticking layer for being dried at the temperature of 40-80 DEG C, and then the mixture are compounded by using PVC or lining materials without woven fabrics and made into the patch of different sizes and specifications by die cutting, thus obtaining the finished product. The patch can not only avoid stimulus to the gastrointestinal tract by oral medication but also reduce the toxic side effect of the medicine by slow release; the release lasts for at least 7 days, thus ensuring lasting and stable therapeutical efficiency; if medicine administration is desired to be halted, removing the patch can achieve the purpose; the patch features convenient use; in addition, the patch is flexible and appropriately adhesive.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to an anastrozole controlled-release patch and a preparation method thereof. Background technique: [0002] Cancer is one of the diseases that seriously endanger human health. According to the statistics of the World Health Organization (WHO), by the 1990s, the incidence of cancer in the world was about 10 million people every year, and about 7 million people died every year. The harm of cancer in the world is becoming more and more serious. In 2000, the number of cancer deaths in my country was 1.4-1.5 million, ranking second among all causes of death and first among urban residents. The number of cancer cases in my country is on the rise. [0003] Breast cancer is one of the most common malignant tumors in women, second only to cervical cancer in incidence. The morbidity and mortality of breast cancer are the highest in Western Europe and North America, and the lowest in Asia, ...

AI Technical Summary

Problems solved by technology

First, the thickness of the skin stratum corneum of hairless mice is only half that of humans, which is not comparable to human transdermal data

Secondly, there is a lack of pharmacokinetic data of anastrozole patches in experimental animals, and the effectiveness and sustained release of anastrozole patches have not been investigated.

Moreover, no definite method for the preparation of the anastrozole patch is proposed

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