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A technology of epimedin and uses, which can be used in medical preparations containing active ingredients, organic active ingredients, bone diseases, etc., and can solve problems such as no relevant reports.
Inactive Publication Date: 2009-08-26
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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As to which component of the total flavonoids of Epimedium plays the main role in the tr
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Embodiment 1
[0070] Embodiment 1 of the present invention: (1) extraction process:
[0071] Take Epimedium medicinal material, cut into pieces, add 20 times of 70% ethanol to reflux three times, each time for 1 hour, combine the three extracts, recover ethanol, and concentrate to a relative density of 1.15 at 60°C. The concentrated solution is added with distilled water in an appropriate amount and placed, the precipitate is discarded, the supernatant is taken, and then concentrated to obtain an extract. Sequentially extract with petroleum ether, chloroform, and ethyl acetate until nearly colorless, then repeatedly extract with n-butanol until nearly colorless, recover n-butanol to dryness, and obtain a crude extract containing Epimedin C.
[0072] (2) Separation process:
[0073] ①Separation by silica gel column chromatography:
[0074] Dissolve the crude extract obtained above in methanol, mix the sample with silica gel for thin-layer chromatography, separate by silica gel column chrom...
Embodiment 2
[0080] Example 2: Prepare Epimedin C according to Example 1, then add water for injection, stir well, adjust the pH value to 5-7, potting, and obtain Epimedin C injection.
Embodiment 3
[0081] Embodiment 3: Prepare Epimedin C extract according to Example 1, add water for injection, stir well, adjust pH value to 5-7, aseptically filter, filtrate is divided into sterilized vials, and freeze-dried to obtain final product Freeze-dried powder preparation.
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Abstract
The invention discloses use of epimedin C in preparing medicament for treating osteoporosis. In examination, under equal dosage, effect of the epimedin C is better than that of epimedium, epimedum total flavone and icariin, and the epimedin C can be used for preparing medicament for treating osteoporosis. Compared with the prior art, under equal dosage, effect of the epimedin C is better than that of epimedium, epimedum total flavone and icariin in treating osteoporosis, and effect of compound medicament of the epimedin C and other medicament (such as estrogen) is better than that of compound medicament of epimedum total flavone and same medicament. Under equal dosage, active component of the epimedin C is higher, and the invention provides a medicament selection with better curative effect for treating osteoporosis.
Description
technical field [0001] The invention relates to the application of epimedin C, an extract of epimedium, and belongs to the technical field of medicines. Background technique [0002] Epimedium is the whole herb of Berberidaceae plants Epimedium brevicornum Maxim. and Epimedium sagittatum (S.et Z.) Maxim. or Epimedium pilose E. Pubescens Maxim. It is one of the traditional Chinese medicines in my country. In recent years, there have been many studies on the effect of Epimedium and its extracts on osteoporosis. For example, Chinese patent 03145167.5 discloses a compound preparation composed of Epimedium and estrogen for treating postmenopausal women's osteoporosis, and discloses that Epimedium and its extract Epimedium total flavonoids can be used to treat osteoporosis disease. Also, Chinese patent 200610065215.7 discloses a traditional Chinese medicine preparation for treating osteoporosis whose main active ingredient is total flavonoids of Epimedium. However, the total fl...
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IPC IPC(8): A61K31/7048A61P19/10
Inventor 王晓春周宁冯泽熹杨昌生罗敏张贵林张金娟郭宝林韦莹曾香兰
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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