Method and kit for detecting susceptibility of ankylosing spondylitis

Abstract

The invention discloses a method for detecting susceptibility of ankylosing spondylitis, which comprises the step of detecting whether transporter antigenic peptides 1 (TPA1), transcripts and / or protein of an individual exist mutation or not compared with normal TPA1, normal transcripts and / or normal protein; and if the mutation exists, the possibility that the individual suffers from the ankylosing spondylitis is larger than the possibility that general group suffers form the ankylosing spondylitis. The invention also discloses a corresponding detecting kit.

Description

technical field

[0001] The present invention relates to the fields of molecular biology and medicine. More specifically, it relates to the single nucleotide polymorphism (singlenucleotide polymorphism, SNP) of antigen peptide transporter 1 (Transporter of Antigen Peptides 1, TAP1) and its correlation with ankylosing spondylitis. The present invention also relates to methods and kits for detecting these SNPs.

[0002] Background technique

[0003] Ankylosing spondylitis, also known as Von Bechterev's disease or Maritstrumpell's disease, is a chronic, progressive, chronic inflammatory disease involving axial joints. It mainly affects the sacroiliac joints, spinal joints and paravertebral tissues of the pelvis. The main symptoms were low back pain, spinal stiffness and limited range of motion, and X-ray showed sacroilitis on both sides. Since the disease generally invades the sacroiliac joints first, and then mainly involves the spine, eventually leading to bony ankylosis of...

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