Livestock cefquinome lung-targeted microspheres and preparation method thereof

Abstract

The invention belongs to the technical field of veterinary drugs. The invention discloses a veterinary drug of cefquinome microspheres serving as a lung-targeted preparation prepared by using cefquinome as a raw material and a preparation method thereof. The cefquinome is used as the raw material and gelatin is used as a carrier to form micropheres, and the ratio of the cefquinome to the gelatin is 1:2. The preparation method comprises the following steps: firstly, dissolving the cefquinome in a solution of the gelatin, uniformly mixing the cefquinome and the solution of the gelatin; secondly, dripping the mixed solution in sorbitanmonooleate and liquid paraffin and uniformly stirring the mixture till the mixture turns milky white; quickly cooling the mixture to below 5 DEG C in an ice bath, adding glutaric dialdehyde in form of thin flow, and continuing stirring for cross linking and curing; dehydrating the product obtained with isopropanol, and performing stirring and suction filtration; and washing the dehydrated product with a small amount of isopropanol and ether to remove the glutaric dialdehyde completely, washing away the liquid paraffin on the surface of the microspheres with petroleum ether and drying the microspheres at room temperature and under vacuum to obtain the cefquinome microspheres. The preparation effectively improves tissue selectivity of drug, slows drug release, improves treatment effect, reduces toxic and side effects, and achieves slow release, long-lasting effect and targeting.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and the invention relates to the preparation of a lung-targeting preparation using cefquinoxime as a raw material - cefquinoxime lung-targeting microspheres and a preparation method thereof. Background technique [0002] Bacterial infectious diseases have always been one of the main diseases that endanger the aquaculture industry, causing serious economic losses to the aquaculture industry. At present, antibacterial drugs are mainly used clinically for the treatment of bacterial infectious diseases, and good results have also been achieved. But in recent years, the use of western medicine has been subject to certain restrictions in the breeding industry due to the following reasons: 1) the generation of drug-resistant strains. 2) The impact of drug residues on humans. 3) Control of drug residues by export groups. 4) Some traditional dosage forms are limited. For these reasons, the...

AI Technical Summary

Problems solved by technology

But in recent years, the use of western medicine has been subject to certain restriction on the breeding industry because of the following reasons: 1) the generation of drug-resistant strain

2) The impact of drug residues on humans

4) Limitations of some traditional dosage forms

At present, most of the dosage forms used clinically are powders and injections. The palatability of powders is poor after use, and the absorption effect is poor. In view of the special physiological structure of livestock, the use of injections is likely to cause greater stress and affect their growth and development.