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Traditional Chinese medicine compound gel for treating osteoporosis and preparation method thereof

A technology of gel and traditional Chinese medicine, which is applied in the field of medicine to achieve the effect of reducing blood drug concentration, reducing toxic and side effects, and prolonging the action time

Inactive Publication Date: 2009-10-14
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the preparation of Aconitum aconitum extract, Yangjinhua extract, Clematis clematis extract, and Shenjincao extract into gels for the treatment of osteoporosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 prepares gel

[0032] Components and ratio:

[0033] Raw Aconitum Extract 1.5g Datura Flower Extract 1g

[0034] Clematis extract 1.5g Clematis extract 2g

[0035] Camphor 0.1g Musk 0.04g

[0036] Hypromellose 1.5g Azone 5ml

[0037] Propylene glycol 15ml Ethylparaben 0.1g

[0038] Add glycerin 10ml distilled water to 120g.

[0039] The preparation method is as follows: add hypromellose to 50 times of distilled water to fully swell, and first dissolve the extract of Aconitum aconitum, extract of Yangjinhua, extract of Clematis clematis, extracts of Shenjincao and camphor according to the above ratio. Dissolve musk in 50ml of 70% ethanol solution and 20ml of ether solution, then add glycerin, azone, propylene glycol, ethyl paraben, add distilled water to 120g, stir evenly to form a gel.

Embodiment 2

[0040] Embodiment 2 prepares gel

[0041] Components and ratio:

[0042] Raw Aconitum Extract 1.5g Datura Flower Extract 1g

[0043] Clematis extract 1.5g Clematis extract 2g

[0044] Camphor 0.1g Musk 0.04g

[0045] Polyvinylpyrrolidone 2g Benzalkonium Bromide 0.2g

[0046] Glycerin 5ml distilled water Add to 120g.

[0047] The preparation method is as follows: add polyvinylpyrrolidone to 75g of distilled water to fully swell, firstly dissolve Aconitum aconitum extract, Dajinhua extract, Clematis extract, Shenjincao extract, and camphor in 50ml of 70ml according to the above ratio. The solution of % ethanol, musk is dissolved in 20ml ether solution, then both add glycerin, benzalkonium bromide, add distilled water to 120g, stir evenly, namely gel.

Embodiment 3

[0048] Embodiment 3 prepares gel

[0049] Components and ratio:

[0050] Raw Aconitum Extract 1.5g Datura Flower Extract 1g

[0051] Clematis extract 1.5g Clematis extract 2g

[0052] Camphor 0.1g Musk 0.04g

[0053] Carbopol 940 1g EDTA-Na 2 0.05g

[0054] Propylene Glycol 10ml Glycerin 5ml

[0055] Triethanolamine 1.5g Distilled water Add to 120g.

[0056] The preparation method is as follows: add Carbopol 940 and 40g of distilled water to swell for 60 minutes, firstly dissolve Aconitum aconitum extract, Yangjinhua extract, Clematis extract, Shenjincao extract and camphor in 50ml of 70% ethanol solution, musk was dissolved in 20ml of ether, and then the two were added to glycerin, EDTA-Na 2 , propylene glycol and triethanolamine, add distilled water to 120g, stir evenly to form a gel.

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Abstract

The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine compound gel for treating osteoporosis, which comprises medicine, macromolecule matrix material, dissolvent, humectant and preservative and can also comprise neutralizing agent and transdermal enhancer, wherein the medicine include unprocessed radix aconite extract, datura flower extract, clematis chinensis extract, common clubmoss herb extract and a small quantity of camphor and muskiness, the macromolecule matrix material can be selected from carbopol, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, hydroxy propyl cellulose and polyvinylpyrrolidone, the dissolvent is water, the humectant is glycerin, the preservative can be selected from hydroxyphenyl ethylester, benzalkonium bromide and EDTA-Na, the neutralizing agent can be selected from sodium hydroxide or trolamine, and the transdermal enhancer can be selected from azone, limonene and propanediol. The traditional Chinese medicine compound gel is applied through skin, thus avoiding stomach and intestinal irritation caused by oral administration, reducing the whole body blood concentration and toxic side effects, prolonging action time, reducing medicine application time and increasing the medicine application compliance of a patient.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to a traditional Chinese medicine compound gel for treating osteoporosis and a preparation method thereof. Background technique: [0002] Osteoporosis is a clinically common and frequently occurring intractable disease, which belongs to the category of arthralgia in traditional Chinese medicine. Epidemiological surveys show that the incidence rate of this disease among middle-aged and elderly people in my country is as high as 70%, among which the incidence rate of cervical spine, lumbar spine and knee joint is the highest, and the three together account for more than 90% of osteoporosis. Stepping into an aging society, this problem will become more prominent. [0003] Existing method for the treatment of osteoporosis, doctor trained in Western medicine usually adopts oral non-steroidal antipyretic analgesics or operation therapy. Oral drugs have many side effects; surgical treatme...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/00A61K47/38A61K47/32A61P19/10A61K35/55A61K31/125
Inventor 蔡郑东汝鸣梁文清吴杭庆郭润生冯文成
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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