Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof

A slow-release drop pill, coating and slow-release technology, which is applied in the direction of pharmaceutical formula, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. Hardness, dripping pills are prone to deformation, rough surface and other problems, to solve the problem of insoluble solubility, reduce the dosage at one time, and increase the weight of the pills less

Inactive Publication Date: 2009-11-04
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the addition of a hydrophobic skeleton material as the matrix, the dropping pills are prone to deformation, tailing, rough surface, increased pill weight, etc.

Method used

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  • Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof
  • Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof
  • Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Selection test of matrix in Pueraria lobata coated dripping pill of the present invention

[0029] Due to the poor water solubility of puerarin, four solid water-soluble PEGs, PEG4000, PEG6000, PEG8000, and PEG10000, were investigated in the early stage of the experiment. It was found that PEG8000 and PEG10000 had large molecular weights and greater viscosity, which was not conducive to the dripping of dripping pills. , PEG4000 has a low viscosity, but PEG6000 has a moderate viscosity. Finally, PEG6000 is chosen as the base of the dripping pill. Through experimental screening, it is found that PEG6000 is better than PEG4000 in the molding, hardness and smoothness of dripping pills. And the dripping pill prepared by using PEG6000 as the dripping pill matrix, in vitro dissolution experiments show that it can significantly increase the dissolution rate of puerarin.

Embodiment 2

[0030] Example 2 Preparation of puerarin-coated dripping pills of the present invention

[0031] (1) Preparation of Puerarin quick-release dripping pill core

[0032] Solid PEGs (PEG1000~20000) are white waxy solids. Among them, PEG4000, PEG8000 and PEG10000 are the most commonly used substrates for solid dispersions. Compared with PEG4000 and PEG8000, PEG6000 has moderate hardness and strong plasticity. Use it as a dripping pill matrix , While improving the dissolution of poorly water-soluble drug puerarin, it can make the surface of the dripping pill smooth, with good color and moderate hardness. After experimental screening, polyethylene glycol 6000 was selected as the matrix, and the puerarin raw material powder was mixed in a certain ratio (10:1~3:1), and the dripping pill core was prepared by the dripping machine by the melting method, and the melting temperature was 70. ~90℃, the temperature of the liquid medicine is 60~80℃.

[0033] Puerarin powder is passed through a 200-...

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Abstract

The invention provides a puerarin lagging cover slowly-releasing dripping pill which is formed by preparing puerarin quickly-releasing dripping pill core through slowly-releasing lagging cover, wherein the puerarin quickly-releasing dripping pill core is formed by preparing PEG6000 as matrix, and the proportioning by weight of puerarin to PEG6000 is 10:1-3:1. The invention also provides a method for preparing the slowly-releasing dripping pill. In the invention, puerarin is prepared into lagging cover slowly-releasing dripping pill, thereby remarkably increasing the dissolution to solve the problem of difficult dissolution, improving the oral bioavailability and achieves the aim of slow release by controlling the release through the lagging cover.

Description

Technical field [0001] The invention relates to a puerarin coated sustained-release dripping pill, which belongs to the field of medicine. Background technique [0002] Puerarin (pue) is a flavonoid glycoside extracted from the roots of leguminous plants Pueraria labata and Puerarin thomsonii. It belongs to flavonoids and its chemical name is 8-C-β-D- Glucose-7,4'-dihydroxy-isoflavones have a molecular weight of 416. Its structural formula is as follows: [0003] [0004] Puerarin is mainly used clinically for coronary heart disease, hypertension, hyperviscosity, cerebral infarction, vertebral-basal artery insufficiency, diabetes, glaucoma, ischemic optic neuropathy and other ophthalmic diseases, sudden deafness, etc., its injection is easy Causes acute intravascular hemolysis, it is forbidden for people with allergies, and the elderly should be used with caution. At present, cardiovascular and cerebrovascular diseases are the leading cause of adult death in my country. As a ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/352A61K47/34A61K47/38A61P3/06A61P3/10A61P9/10A61P9/12A61P27/02A61P27/06A61P27/16A61K47/10
Inventor 高秀蓉臧志和许小红张永模胡霞
Owner CHENGDU MEDICAL COLLEGE
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