Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof

A slow-release drop pill, coating and slow-release technology, which is applied in the direction of pharmaceutical formula, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. Hardness, dripping pills are prone to deformation, rough surface and other problems, to solve the problem of insoluble solubility, reduce the dosage at one time, and increase the weight of the pills less

Inactive Publication Date: 2011-03-30
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the addition of a hydrophobic skeleton material as the matrix, the dropping pills are prone to deformation, tailing, rough surface, increased pill weight, etc.

Method used

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  • Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof
  • Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof
  • Puerarin lagging cover slowly-releasing dripping pill and preparing method thereof

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Effect test

Embodiment 1

[0028] The selection test of matrix in the pueraria root coated dripping pill of the present invention

[0029] Due to the poor water solubility of puerarin, four solid water-soluble PEGs, PEG4000, PEG6000, PEG8000, and PEG10000, were investigated as carriers in the early stage of the test. It was found that PEG8000 and PEG10000 were not conducive to the dripping pills because of their large molecular weight and high viscosity. , The viscosity of PEG4000 is relatively small, while the viscosity of PEG6000 is moderate, and finally PEG6000 is selected as the dropping pill matrix. Through experimental screening, it is found that PEG6000 is used as the matrix, which is better than PEG4000 in terms of the shape, hardness and smoothness of the dropping pills. And by using PEG6000 as the drop pill matrix, the in vitro dissolution test shows that it can significantly increase the dissolution rate of puerarin.

Embodiment 2

[0030] The preparation of embodiment 2 puerarin-coated dropping pills of the present invention

[0031] (1) Preparation of puerarin quick-release dropping pill core

[0032] Solid PEGs (PEG1000-20000) are white waxy solids, among which PEG4000, PEG8000 and PEG10000 are the most commonly used substrates for solid dispersions, and compared with PEG4000 and PEG8000, PEG6000 has moderate hardness and strong plasticity, so it is used as the matrix of dropping pills , while improving the dissolution rate of puerarin, a poorly water-soluble drug, it can also make the surface of the dropping pills smooth, with good color and moderate hardness. After experimental screening, polyethylene glycol 6000 was selected as the matrix, and it was mixed with puerarin raw material drug powder in a certain ratio (10:1~3:1), and the dropping pill core was prepared by melting method with a dropping pill machine, and the melting temperature was 70 ~90°C, and the temperature of the liquid medicine is ...

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Abstract

The invention provides a puerarin lagging cover slowly-releasing dripping pill which is formed by preparing puerarin quickly-releasing dripping pill core through slowly-releasing lagging cover, wherein the puerarin quickly-releasing dripping pill core is formed by preparing PEG6000 as matrix, and the proportioning by weight of puerarin to PEG6000 is 10:1-3:1. The invention also provides a method for preparing the slowly-releasing dripping pill. In the invention, puerarin is prepared into lagging cover slowly-releasing dripping pill, thereby remarkably increasing the dissolution to solve the problem of difficult dissolution, improving the oral bioavailability and achieves the aim of slow release by controlling the release through the lagging cover.

Description

technical field [0001] The invention relates to a puerarin-coated sustained-release dripping pill, which belongs to the field of medicines. Background technique [0002] Puerarin (pue) is a flavonoid glycoside extracted from the roots of the leguminous plants Pueraria labata and Pueraria thomsonii. It belongs to flavonoids and its chemical name is 8-C-β-D- Glucose-7,4'-dihydroxy-isoflavone with a molecular weight of 416. Its structural formula is as follows: [0003] [0004] Puerarin is mainly used clinically for coronary heart disease, hypertension, hyperviscosity, cerebral infarction, vertebral-basilar artery insufficiency, diabetes, glaucoma, ischemic optic neuropathy and other eye diseases, sudden deafness, etc. Its injection is easy to Cause acute intravascular hemolysis, contraindicated for those with allergies, and used with caution in the elderly. At present, cardiovascular and cerebrovascular diseases are the leading cause of death in adults in my country. As...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/352A61K47/34A61K47/38A61P3/06A61P3/10A61P9/10A61P9/12A61P27/02A61P27/06A61P27/16A61K47/10
Inventor 高秀蓉臧志和许小红张永模胡霞
Owner CHENGDU MEDICAL COLLEGE
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