Application of total flavone of scutellaria barbata for preparing anti-dementia medicine

Abstract

The anti-dementia medicine prepared from scutellaria barbata is invented for making up for a deficiency of clinical anti-dementia medicines. A series of experimental studies for years verify that the total flavone of the scutellaria barbata has obvious function of nerve protection, anti-dementia and memory improvement. The invention comprises the following steps of: pulverizing clean scutellaria barbata; carrying out the inverse flow of ethanol 20 times as much as the scutellaria barbata for 1 hour and filtering; carrying out the inverse flow of ethanol 20 times as much as dregs for 1 hour and filtering again; mixing the filtrate obtained twice; thoroughly recycling the ethanol after 60-DEG C decompression; adsorbing chlorophyll by adding 3% calcium carbonate to the residual liquid; standing for a night; carrying out suction filtration; regulating the filtrate to a pH value of 2 or so with acid; and obtaining the total flavone extract by centrifugal precipitation, 60-DEG C drying and the like. In the total flavone extract, the total content of the flavone is not less than 70% and can be prepared into tablets, capsules, oral liquid or injection. The Scutellaria barbata is abundant in nature or can be cultivated artificially with low cost, and the quality of the artificially-cultivated medicinal material is similar to the natural. The experiment proves that the anti-dementia medicine prepared from the total flavone of scutellaria barbata has positive clinical function, high efficiency and low toxicity, thereby having wide development foreground.

Description

Technical field:

[0001] The invention belongs to the technical field of drug development, and in particular relates to a new medical application of Chinese herbal medicine Scutellaria barbata and a preparation of total flavonoids of Scutellaria barbata. technical background:

[0002] In the 21st century, senile dementia has become a common and frequently-occurring disease, which seriously threatens the health of human beings in their later years. Since the 1980s, a series of drug studies for the treatment of dementia have been carried out at home and abroad. For example, VitE and selegiline (applied for 2 years) can delay the development of senile dementia, but no improvement in memory and completion of patients has been observed. Intellectual work ability; Ginkgo preparation EGB7616 has been listed in Germany and the United Kingdom as a drug for treating dementia. ,E 2020 , Huperzine-A) also play the role of improving memory impairment from inhibiting cholinesterase activ...