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Yinxingdamo oral preparation equivalent to similar intravenous preparation

A technology for oral preparations and compositions, applied in the field of oral solid preparations, can solve problems such as low bioavailability, destruction of active ingredients, influence on curative effect, etc., and achieve the effects of easy transportation and storage, remarkable drug effect, and convenient and flexible taking.

Inactive Publication Date: 2009-12-02
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The object of the present invention is to overcome the inconvenience of clinical intravenous administration of the existing Ginkgo Damole injection (intravenous injection, twice a day) and the slow onset of action of the corresponding unilateral oral preparation, low bioavailability, and poor absorption through the gastrointestinal tract (under strong acid). Biodegradation leads to the destruction of some active ingredients and affects the curative effect, further improving the quality stability and bioavailability of ginkgo damole oral preparations

Method used

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  • Yinxingdamo oral preparation equivalent to similar intravenous preparation
  • Yinxingdamo oral preparation equivalent to similar intravenous preparation
  • Yinxingdamo oral preparation equivalent to similar intravenous preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dosage Form: Capsules

[0029] Take 40g of ginkgo biloba extract, 0.96g of folic acid, pass through 80 mesh sieve, mix evenly, then add 25.2g of dipyridamole hydrochloride, 250g of starch, 180g of microcrystalline cellulose according to the method of equal increase, and mix well; add an appropriate amount of 20% The soft material made of ethanol is granulated with a 20-mesh sieve, dried at 50°C for 2 hours, granulated with a 18-mesh sieve, and the intermediate content is measured. After passing the test, it is filled with capsules and packaged to obtain 1000 capsules.

Embodiment 2

[0031] Dosage Form: Tablet

[0032] Get 40g of Ginkgo biloba extract (9.6g according to total ginkgo flavonoids), 0.96g of folic acid is passed through an 80 mesh sieve, mix well, then add dipyridamole citrate 35.5g, starch 350g, sucrose 60g, Mix well; add an appropriate amount of 15% ethanol-made soft material, granulate with a 20-mesh sieve, add 5 g of magnesium stearate and mix evenly, measure the content of the intermediate, compress into tablets, and coat to obtain 1000 tablets.

Embodiment 3

[0034] Dosage Form: Granules

[0035] Get 40g of Ginkgo biloba extract (9.6g as total ginkgo flavonoids), 0.96g of folic acid and pass through an 80 mesh sieve, mix well, then add 25.2g of dipyridamole hydrochloride, 210g of starch, 30g of dextrin, sucrose 40g, fully mixed; add an appropriate amount of 20% ethanol soft material, granulate with a 20-mesh sieve, dry at 50°C for 1.5 hours, and granulate with a 18-mesh sieve to obtain 350g of granules.

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Abstract

The invention provides a Yinxingdamo oral preparation equivalent to similar intravenous preparation, containing two main drugs: ginkgo leaf extract dipyridamole glucuronide which have the weight ratio of 1:1-4. In addition to the main drugs, the invention also comprises vitamins, glutathione, folic acid and the like as antioxidant, and can further comprise common pharmaceutic adjuvants of binding agent, flow agent, disintegrant, filler and the like. The preparation can be oral liquid preparation, such as tablets, capsules, granules, pills, soft capsules, oral liquid, etc. Compared with the existing ginkgo extract injection, the preparation of the invention has controllable product quality, good stability, long retention period and convenient clinic use.

Description

technical field [0001] The invention relates to an oral solid preparation with ginkgo leaf extract and dipyridamole as main raw materials, in particular to an oral enteric-coated ginkgo damole preparation composition equivalent to similar intravenous preparations and a preparation method thereof. Background technique [0002] Ginkgo biloba extract contains ginkgo total flavonoid glycosides (such as quercetin, kaempferol, isorhamnetin, etc.), ginkgolides (mainly ginkgolides A, B, C and bilobalide), modern pharmacological research It has been shown that ginkgo flavonoid glycosides have a strong antioxidant effect, can remove the remaining free radicals in the body, prevent lipid peroxidation in the body, regulate blood vessel tension, protect capillary permeability, improve microcirculation and blood rheology, and reduce blood viscosity , reduce the damage of harmful substances, protect nerve cells, nourish brain cells and other organs. [0003] Ginkgolide is a platelet activ...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K47/22A61K47/42A61P7/02A61P9/10A61P9/14A61P25/00A61P25/28A61P27/02A61P27/16A61K31/519A61K47/18
Inventor 安英张玲玲张慧英陈华
Owner 北京瑞伊人科技发展有限公司
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