Medicament for treating constipation

A technology for treating constipation and drugs, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems such as toxic side effects and patient safety issues, and achieve low-cost effects

Inactive Publication Date: 2009-12-02
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Generally, when patients suffer from constipation, they are usually treated with medicaments, mostly oral medicines or injections, but both oral medicines and injections have toxic and side effects, and they will produce a reaction through the first-pass effect of the liver and the release of the digestive tract. raise security concerns

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the medicine for treating constipation (trade name: treating constipation ointment)

[0020] Prescription: hemp seed 150g, almond 100g, melon 150g.

[0021] Preparation:

[0022] A. Extraction process

[0023] (a) Take 3 herbs such as hemp seeds, decoct them twice with water, first use 8 times the amount of water, decoct for 2 hours, and use 6 times the amount of water for the second time, decoct for 2 hours, filter, and combine the filtrates , concentrated under reduced pressure to a relative density of 1.25, left to cool at room temperature, added ethanol to make the alcohol content 70%, stirred well, allowed to stand for 12 hours to precipitate, took the supernatant to recover ethanol, concentrated under reduced pressure to a relative density of 1.40 Thick paste, vacuum-dried at 65°C to obtain dry matter, crushed, and passed through a 100-mesh sieve,

[0024] (b) taking the above-mentioned medicated powder and superfinely pulverizing it into an ultra...

Embodiment 2

[0028] Embodiment 2: the medicine for treating constipation (trade name: treating constipation cataplasm)

[0029] Prescription: hemp seed 150g, almond 100g, melon 150g.

[0030] Preparation:

[0031] A. Extraction process:

[0032] (a) Take 3 herbs such as hemp seeds, decoct them twice with water, first use 8 times the amount of water, decoct for 2 hours, and use 6 times the amount of water for the second time, decoct for 2 hours, filter, and combine the filtrates , concentrated under reduced pressure to a relative density of 1.25, left to cool at room temperature, added ethanol to make the alcohol content 70%, stirred well, allowed to stand for 12 hours to precipitate, took the supernatant to recover ethanol, concentrated under reduced pressure to a relative density of 1.40 Thick paste, vacuum-dried at 65°C to obtain dry matter, crushed, and passed through a 100-mesh sieve;

[0033] (b) Get the above-mentioned medicated powder and ultrafinely pulverize it into an ultrafin...

Embodiment 3

[0037] Embodiment 3: investigation on the stability of the medicinal ointment for the treatment of constipation

[0038] According to the "Technical Requirements for New Drug Research of Traditional Chinese Medicine" promulgated and implemented by the State Drug Administration, the technical requirements for quality stability research of new traditional Chinese medicines are stipulated. The ointment and cataplasm for treating constipation are made according to the established process, and the properties, moisture retention, content and microbiological inspection items are observed at room temperature. The results show that all the control indicators meet the national ointment quality standards, and the quality is stable after being placed at room temperature for six months.

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Abstract

The invention provides a medicament for treating constipation, which comprises effective components of edestan, almond and trichosanthes kirilowii maxim, has the functions of moistening dryness, smoothing intestinal tracts, clearing and relaxing the bowels and is effective to treat intestinal tract dryness, constipation and appearance of deficient and excessive syndromes, wherein an ointment is fine and smooth and easy to coat without melting and has small volume and convenient use and carrying; and cataplasma has stable medicinal property and the characteristics of quick percutaneous absorption, good air permeability, gradual medicine release, and the like. Compared with an oral formulation, the medicament has no intestinal tract first pass effect, is not influenced by the degradation of gastrointestinal tracts and has high bioavailability; compared with an injection, the medicament has convenient use and no pain; compared with the cataplasma, the medicament has accurate dosage and fixed absorption area; and compared with a black plaster and an adhesive plaster, the medicament has no phenomena of skin allergy and clothing pollution and has the advantages of long-term action, skin absorption and convenient carrying and use.

Description

technical field [0001] The invention relates to the technical field of digestive system medicines, in particular a medicine for treating constipation which is made from Chinese medicinal materials. Background technique [0002] Constipation is a clinically common disease. The lesions are mainly in the liver, spleen, kidney, stomach, and large and small intestines. It is often related to factors such as exposure to external pathogens, injury from diet, emotional disorders, and weakness of viscera. The existing bibliographical report of the medicine of treating constipation with traditional Chinese medicine. [0003] Generally, when patients suffer from constipation, they are usually treated with medicaments, mostly oral medicines or injections, but both oral medicines and injections have toxic and side effects, and they will produce a reaction through the first-pass effect of the liver and the release of the digestive tract. bring about security issues. Contents of the inv...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/06A61K9/70A61P1/10
Inventor 李建民梁友
Owner TIANJIN ZHONGBAO PHARMACY
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