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Soft capsule and preparation method thereof

A technology of soft capsules and soft capsule skins, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as leakage, soft capsule skin degeneration, local deformation, etc., and achieve uniform toughness and softness , Guarantee the effect of activity and full glue

Active Publication Date: 2011-04-06
BEIJING HANGYANG CAPSULE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, what the present invention is to solve is that after the soft capsules in the prior art are coated with the contents of Chinese medicines, the activity of the active ingredients of Chinese medicines will be affected due to the reaction between the natural acid in the Chinese medicines or the natural aldehydes and ketones and the soft capsule skin, And the problems that lead to the degeneration, leakage, and local deformation of the soft capsule skin, and then provide a method that can isolate the content from the soft capsule skin to ensure the active ingredients of the Chinese medicine content and the soft capsule skin. Partially deformed soft capsules

Method used

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  • Soft capsule and preparation method thereof
  • Soft capsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) To make an inner coating film, weigh 41 g of liquid paraffin, 13 g of povidone K30, 16 g of polyacrylic acid resin II, 25 g of polyvinyl alcohol 400, 5 g of citric acid, and 95 g of salad oil. Fully mix the above raw materials in the coating liquid storage tank, emulsify at a temperature of 50°C, emulsify for 40 minutes until the material liquid is evenly mixed, and then stand at room temperature for later use;

[0027] Wherein, liquid paraffin, povidone K30, polyacrylic acid resin II, polyvinyl alcohol 400, citric acid are solutes, and salad oil is a solvent.

[0028] (2) making capsule skins, fully mixing the raw materials for producing capsule skins in glue tank 1 for subsequent use;

[0029] (3) melt the mixture in the glue tank 1 in step (2) at a temperature of 60° C. for 2 hours to obtain glue;

[0030] (4) The glue liquid obtained after melting the glue in the glue tank 1 through the step (3) flows into the rubber box 2 through the rubber tube, and the glue ...

Embodiment 2

[0035] Prepare soft capsule of the present invention, comprises the steps:

[0036] (1) To make an inner coating film, weigh 25g of liquid paraffin, 15g of povidone K3015g, 20g of polyacrylic acid resin II, 40030g of polyvinyl alcohol, 10g of citric acid and 130g of salad oil. Fully mix the above raw materials in the coating liquid storage tank, emulsify at a temperature of 40°C, emulsify for 3 hours until the material liquid is evenly mixed, and let it stand at room temperature for later use;

[0037] Wherein, liquid paraffin, povidone K30, polyacrylic acid resin II, polyvinyl alcohol 400, citric acid are solutes, and salad oil is a solvent.

[0038] (2) making capsule skins, fully mixing the raw materials for producing capsule skins in glue tank 1 for subsequent use;

[0039](3) melt the mixture in the glue tank 1 in step (2) at a temperature of 75° C. for 0.6 hours to obtain glue;

[0040] (4) The glue liquid obtained after melting the glue in the glue tank 1 through the ...

Embodiment 3

[0045] Prepare soft capsule of the present invention, comprises the steps:

[0046] (1) To make an inner coating film, weigh 50g of liquid paraffin, 10g of povidone K3010g, 10g of polyacrylic resin II, 40020g of polyvinyl alcohol, 10g of citric acid and 60g of salad oil. Fully mix the above raw materials in the coating liquid storage tank, emulsify at a temperature of 60°C, emulsify for 30 minutes until the material liquid is evenly mixed, and stand at room temperature for later use;

[0047] Wherein, liquid paraffin, povidone K30, polyacrylic acid resin II, polyvinyl alcohol 400, citric acid are solutes, and salad oil is a solvent.

[0048] (2) making capsule skins, fully mixing the raw materials for producing capsule skins in glue tank 1 for subsequent use;

[0049] (3) melt the mixture in the glue tank 1 in step (2) at a temperature of 55° C. for 4 hours to obtain glue;

[0050] (4) The glue liquid obtained after melting the glue in the glue tank 1 through the step (3) fl...

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Abstract

A soft capsule comprises content and soft capsule skin as well as a layer of inner coating membrane which is located between the content and the soft capsule skin. The inner coating membrane comprises solute and solvent, the solute consists of liquid paraffin 25-50, polyvidone K30 5-15, polyacrylic acid resin II 10-20, polyving akohol 400 10-30 and citric acid 2.5-10 according to mass percentage;the solvent is salad oil, the content of which is 60-130% of the content of the solute. The invention aims at solving the problem of influence on the activity of effective constitutes in traditional Chinese medicine and soft capsule skin deterioration, leakage and partial deformation caused by reaction between the soft capsule skin and natural acid or natural aldehyde ketone in the traditional Chinese medicine after the soft capsule wraps the traditional Chinese medicine content in the prior art, thus providing the soft capsule capable of separating the soft capsule skin from the content and ensuring the activity of effective constitutes in traditional Chinese medicine and no soft capsule skin deterioration, or no leakage or no partial deformation.

Description

technical field [0001] The present invention relates to a capsule. In particular, it relates to a soft capsule and a preparation method thereof. Background technique [0002] At present, soft capsules mainly adopt the structural method of wrapping the contents with the soft capsule skin, that is, the contents are used as the central substance, and the soft capsule skin is located on the outer layer to cover the contents. Use ordinary soft capsules to cover the contents, and the general way of administration is to disintegrate after entering the human body through the throat. On the one hand, this method cannot achieve targeted control of the administration position of soft capsules. Or the treatment effect of stomach diseases will be affected by the degree; on the other hand, most drugs have stimulating effects on the human stomach, and this type of administration method is prone to release due to the disintegration of the drug mainly in the throat or stomach. And stimulat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/44A61K47/34A61K47/32A61K47/12A61J3/07A61K47/10
Inventor 霍晋涛周洋程鹏
Owner BEIJING HANGYANG CAPSULE TECH
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