Ursodeoxycholic acid nano suspension and preparation method thereof
A technology of ursodeoxycholic acid and nano-suspension, which is applied in the direction of pharmaceutical formulas, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as being left behind, increase absorption opportunities, improve Wettability, the effect of solving physical stability problems
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Examples
Embodiment 1
[0032] Weigh 2 g of ursodeoxycholic acid raw material, 0.16 g of PVP K30 and 0.04 g of SDS, add 40 mL of double distilled water, stir well, ultrasonically emulsify with 8000 rpm probe for 2 min; The preparation conditions were 2 cycles at 200 bar, 2 cycles at 500 bar, and 20 cycles at 1500 bar to obtain a milky white nanosuspension with a measured particle size of 356 nm, PI 0.13, and zeta potential of -48 mv.
Embodiment 2
[0034] Weigh 2 g of ursodeoxycholic acid raw material, 0.16 g of PVP K30 and 0.04 g of SDS, add 40 mL of double distilled water, stir well, ultrasonically emulsify with 8000 rpm probe for 2 min; The preparation conditions were 2 cycles at 200 bar, 2 cycles at 500 bar, 2 cycles at 1000 bar, and 10 cycles at 1500 bar to obtain a milky white nanosuspension with a measured particle size of 380 nm, PI 0.15, and zeta potential of -45 mv.
Embodiment 3
[0036]Weigh 2 g of ursodeoxycholic acid raw material, 0.1 g of PVP K30 and 0.1 g of SDS, add 40 mL of double distilled water, stir well, ultrasonically emulsify with 8000 rpm probe for 2 min; The preparation conditions were 2 cycles at 200 bar, 2 cycles at 500 bar, and 20 cycles at 1500 bar to obtain a milky white nanosuspension with a measured particle size of 420 nm, PI 0.17, and zeta potential of -35 mv.
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Abstract
Description
Claims
Application Information
- IPC
- A61K9/10; A61K9/14; A61K31/575; A61K47/32; A61K47/20; A61P1/16
- Inventors
- 袁海龙; 黄雪