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Micro-channel unit module, fluid concentration gradient generator and flow resistance measurer

A concentration gradient and unit module technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effect of reducing preparation time, reducing dependence and maintaining stability

Active Publication Date: 2013-06-19
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is simple and easy to implement, but because the integrated preparation is considered during processing, it can only measure the pressure at a fixed position

Method used

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  • Micro-channel unit module, fluid concentration gradient generator and flow resistance measurer
  • Micro-channel unit module, fluid concentration gradient generator and flow resistance measurer
  • Micro-channel unit module, fluid concentration gradient generator and flow resistance measurer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: Design of fluid rheostat module:

[0098] Such as figure 2 As shown, the shape of the designed pipeline is a serpentine pipeline. The width of the pipe is 100 microns and the height is 28 microns. At the end of the pipe, at the turn, and near the end of the pipe, there are marks of the interface connected to the outside world. According to formula (2), when the height and width of the pipe are equal, the flow resistance is proportional to the length of the pipe. exist figure 2 In , the distance from ho to h1 is 2 mm, which is set as a unit length, that is, the flow resistance value between ho and h1 is 1. The distance from h3 to ho is 6 mm, so its flow resistance value is 3. Similarly, the flow resistances from ho to h5, ho to h7, he to h2, he to h4, he to h6 are 5, 7, 2, 4, 6 respectively. The distance between any two adjacent interfaces (such as a and b) in the middle of the meandering pipeline is always 14 mm, so its flow resistance is 7. In th...

Embodiment 2

[0099] Example 2: Occurrence of a linear concentration gradient:

[0100] Select the fluid splitting module in Figure 1 ( Figure 1-2 to Figure 1-5 module shown), collection module ( Figure 1-8 or Figure 1-9 module shown) and the drive pump;

[0101] Such as image 3 As shown, the structure is as follows: the inlets of the two linear input flow channels of the first fluid distribution module are respectively connected with the raw liquid drive pump and the diluent drive pump; the outlets of the three linear output flow channels of the first fluid distribution module are respectively It is connected with the three linear output channel inlets of the second fluid splitting module; by analogy, the five linear output channel outlets of the fourth fluid splitting module are respectively connected with the four linear micro-channel inlets; the fourth The five linear microchannel outlets of each fluid splitting module are respectively connected with Figure 1-8 or Figure 1-9...

Embodiment 3

[0108] Occurrence of an arbitrary concentration gradient:

[0109] Select the shunt module in Figure 1 ( Figure 1-6 module shown), fluid rheostat module ( Figure 1-7 modules shown) and receive

[0110] set module ( Figure 1-8 or Figure 1-9 module shown) and the drive pump.

[0111] 1, according to Figure 5 The connection method in connects the above-mentioned modules. It is worth noting that, due to the limitation of drawing, Figure 5 Only 2 rheostat modules (actually can be designed into multiples according to needs) and 2 confluence modules (actually can be designed into multiples according to needs) are given in , so only 4 solutions with different concentrations can be produced ; If the given example uses 7 rheostat modules and 7 merging modules, the rheostat modules and Figure 5 As shown in , they are all connected under the shunt module on the right.

[0112] 2. Draw the 12mg / L sodium fluorescein that needs to produce a concentration gradient as the origi...

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Abstract

The invention relates to a functional micro-channel unit module, a fluid concentration gradient generator and a flow resistance measurer. The micro-channel unit module relates to a fluid-shunting module, a fluid-converging module, a fluid variable resistance module, a fluid-collecting module, a fluid speed-adjusting module, and the like. Suitable micro-channel unit modules can be selected as required to construct different micro-flow network systems, such as the flow resistance measurer for measuring the flow resistance of fluid, a fluid linearity concentration gradient generator for operating the fluid and generating a concentration gradient of the fluid, a fluid arbitrary concentration gradient generator, and the like, thereby greatly shortening the preparation time of a concentration gradient device, lessening the reliance on micro-processing equipment, randomly replacing a damaged module in a modularized system and keeping the stability of the system. The invention can be widely applied to physical, chemical and biological fields.

Description

technical field [0001] The invention relates to a chip composed of a micro-channel unit and its application field, in particular to a micro-channel unit module, a fluid concentration gradient generator and a flow resistance measuring device. Background technique [0002] As a powerful tool for manipulating tiny volumes of fluids, microfluidics has been increasingly used in chemistry, biology, and medicine. The characteristic of microfluidics is that by preparing the pipeline through which the fluid flows to a micron size, the entire path through which the fluid flows can be limited to a small chip, which is microfluidic chip technology. In microfluidics, because the size of the fluid becomes smaller, the flow state is characterized by laminar flow, which can be described by more accurate physical equations. In addition, the reduction in size also brings about an increase in the specific surface area of ​​the fluid. A large specific surface area is beneficial to increase t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N31/00G01N33/00G01N35/08
Inventor 蒋兴宇孙康
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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