Method for making three-dimensional visualization model of internal structure of bone

Abstract

The invention is a method for making a three-dimensional visualization model of the internal structure of bone. In the method, a dry bone specimen is embedded and fixed by transparent polymethyl methacrylate (PMMA) to form a model specimen, and then the cross-section of the specimen is ground layer by layer, two-dimensional grayscale images and true color images are scanned and recorded layer by layer, and then three-dimensional medical reconstruction software is used to obtain high-precision three-dimensional visual model of a proximal bone structure. The invention can be applied to three-dimensional reconstruction of bones of human bodies and animals, thereby obtaining the high-precision three-dimensional visual model which can objectively, truly and completely reflect the proximal bone structure. The method can carry out certain evaluation on the structural form of bone trabecula as well as the connectivity of three-dimensional bone trabecular, and can determine the structural parameters of bone trabecular, thus providing scientific basis for medical research and clinical care.

Description

【Technical field】 [0001] The invention relates to a method for making a bone internal structure model, in particular to a method for making a digitized three-dimensional visualization model of the bone internal structure. 【Background technique】 [0002] Trabecular bone, located at the ends of long bones such as the femur and in cubic bones such as the spine, is the major biological tissue-carrying tissue in the human skeleton. Due to the complexity of the force of this type of bone, such as the femur, and the anisotropy of cancellous bone, its special intraosseous structure is formed. The intraosseous structure of the femoral head and femoral neck interweaves into a network of dense lamellae arranged in an orderly manner, and forms five groups: main pressure trabeculae, main force trabeculae, secondary pressure trabeculae, secondary tension trabeculae, and greater trochanteric trabeculae Trabecular. The arrangement direction of the trabeculae is mainly along the principal ...

AI Technical Summary

Problems solved by technology

[0003] Although the existing research methods in the study of bone structure are diverse, they all have their own shortcomings: the three-dimensional reconstruction based on CT and MRI can display the arrangement trend of the proximal femoral trabeculae, but due to the different image processing methods, CT and MRI Different sensitivity to bone and soft tissue and other reasons limit the clear display of the microstructure of bone trabecula

However, at present, micro-CT is mainly used in the research of biopsy specimens and small animals. Since it can only scan a small area of ​​interest, a limited range of data can be obtained.

At the same time, the X-ray irradiation necessary to obtain high resolution also limits its application in the human body.

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