Method for preparing capsicine monomer

A technology for capsaicin and dihydrocapsaicin, which is applied in the field of biomedicine, can solve the problems of complicated separation and purification process, unfavorable large-scale production and high cost, and achieves the effects of wide source of raw materials, low equipment requirements and easy operation.

Inactive Publication Date: 2010-01-06
厦门绿启源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is to solve the problems of complicated separation and purification process

Method used

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  • Method for preparing capsicine monomer
  • Method for preparing capsicine monomer
  • Method for preparing capsicine monomer

Examples

Experimental program
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Effect test

Embodiment 1

[0044] (1) Measure 1L of capsicum essential oil in a 5L beaker, add 3L of 75% alcohol, stir and extract at 30°C for 2 hours, and after standing for 1 hour, the supernatant is obtained;

[0045] (2) the supernatant is decompressed and concentrated to remove alcohol to obtain a capsaicin concentrate, and the recovered alcohol is recycled;

[0046] (3) The concentrated solution is directly loaded on the column for adsorption, wherein the volume of the adsorption column is 377cm3 (the diameter of the adsorption column is 4cm, and the height is 30cm), and the flow rate of the upper column is 500ml / h;

[0047] (4) When the product is completely absorbed, elute with 15% alcoholic water solution until the effluent is clear and colorless, so as to remove impurities and pigments; then use 1.2L 30% alcoholic water solution Carry out elution and collect the effluent, denoted as A; then elute with 1.2L 45% alcohol aqueous solution, collect the effluent, denote as B; finally use 1.2L 75% al...

Embodiment 2

[0056] (1) Weigh 1 kg of dry red chili powder in a 5L beaker, add 3L of 50% alcohol, stir and extract at 30°C for 8 hours, and after standing for 1 hour, obtain the supernatant;

[0057] (2) the supernatant is decompressed and concentrated to remove alcohol to obtain a capsaicin concentrate, and the recovered alcohol is recycled;

[0058] (3) The concentrated solution is directly adsorbed on the column, and the volume of the adsorption column is 377cm 3 (The diameter of the adsorption column is 4cm, the height is 30cm), and the flow rate of the upper column is 500ml / h;

[0059] (4) When the product is completely absorbed, elute with 20% alcoholic water solution until the effluent is clear and colorless, so as to remove impurities and pigments; then use 1.2L 35% alcoholic water solution Carry out elution and collect the effluent, denoted as A; then elute with 1.2L 50% alcohol aqueous solution, collect the effluent, denote as B; finally use 1.2L 70% alcohol aqueous solution for...

Embodiment 3

[0068] (1) Measure 100L chili essential oil in 1m 3 In a stainless steel extraction tank, add 300L 75% alcohol, stir and extract at 30°C for 3 hours, and after standing for 1 hour, the supernatant is obtained;

[0069] (2) the supernatant is decompressed and concentrated to remove alcohol to obtain a capsaicin concentrate, and the recovered alcohol is recycled;

[0070] (3) The concentrated solution is directly loaded onto the column for adsorption, wherein the volume of the adsorption column is 500L (the diameter of the adsorption column is 50cm, and the height is 2.55m), and the flow rate of the column is 800L / h;

[0071] (4) When the product is completely absorbed, elute with a 15% alcohol solution until the effluent is clear and colorless, so as to remove impurities and pigments; then use 1.5m 3 30% ethanol aqueous solution for elution, and collect the effluent, denoted as A; then use 1.5m 3 45% ethanol aqueous solution was used for eluting, and the effluent was collec...

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Abstract

The invention relates to a purifying method of natural functional components and provides a method for preparing capsicine monomers. The method for preparing capsicine monomers comprises the following technical steps of extracting capsicum essential oil or capsicum powder by alcohol, separating and purifying macroporous absorbent resin, recrystallizing a monomer crude product, and the like. The method for preparing a capsicine monomer extracts three capsicine monomers from the capsicum essential oil or the capsicum powder, has simple technology and low production cost, does not use a harmful organic solvent in a production process and is easy to realize industrialized production. The purity of capsicine, dihydrocapsaicine and a falling dihydrocapsaicine monomer which are produced by the method is larger than 98 percent, and the yield of the capsicine, the dihydrocapsaicine and the falling dihydrocapsaicine monomer are larger than 85 percent. The method for preparing capsicine monomers lays a solid foundation for the wide application of high-purity capsicine monomers.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a method for purifying natural functional components, in particular to a method for separating and purifying capsaicin monomer from capsicum essential oil or capsicum powder Background technique [0002] Natural capsaicinoids (Capsaicinoids) produced from peppers are the spicy ingredients in pepper fruits. It has been found to be a class of vanillyl amide alkaloids with a similar structure composed of at least 14 components, of which there are mainly three components: capsicum Alkali (Capsaicin), dihydrocapsaicin (Dihydrocapsaicin) and nordihydrocapsaicin (Nordihydrocapsaicin), the sum of these three components accounts for more than 96% of the total amount of capsaicin. Wherein the main ingredient is capsaicin, accounting for about 69%, followed by dihydrocapsaicin, accounting for about 22%, and nordihydrocapsaicin accounting for about 5%. The structural diagrams of capsaicin, dihydroca...

Claims

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Application Information

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IPC IPC(8): C07C233/20C07C233/18C07C231/24B01D15/08B01D15/42
Inventor 张鹏张淑荣刘春巧
Owner 厦门绿启源生物科技有限公司
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