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Method for anchoring on surface of Fe3O4 nanoparticles and polymer-Fe3O4 hybrid magnetic nanoparticles preparation method

A nano-particle and nano-technology, applied in the direction of magnetic materials, magnetic objects, organic materials/organic magnetic materials, etc., can solve the problems of cumbersome preparation and post-processing, complicated operation, etc., achieve mild conditions, simple operation, and solve Effects of Dispersion Problems

Inactive Publication Date: 2010-01-20
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The key to RAFT active polymerization on the surface of nanoparticles is to try to introduce RAFT chain transfer agent (or RAFT agent) to the surface of nanoparticles. The reported method is usually introduced by chemical coupling method, but this method involves multi-step chemistry. The reaction, preparation and post-treatment process are cumbersome and the operation is complicated
For Fe 3 o 4 As far as magnetic nanoparticles are concerned, the method of introducing RAFT agents on their surface has not been reported yet.

Method used

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  • Method for anchoring on surface of Fe3O4 nanoparticles and polymer-Fe3O4 hybrid magnetic nanoparticles preparation method
  • Method for anchoring on surface of Fe3O4 nanoparticles and polymer-Fe3O4 hybrid magnetic nanoparticles preparation method
  • Method for anchoring on surface of Fe3O4 nanoparticles and polymer-Fe3O4 hybrid magnetic nanoparticles preparation method

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1: Nano Fe 3 o 4 -DDMAT preparation

[0022] In a dry reactor, 200 mg of oleic acid-stabilized nano-Fe 3 o 4 (10nm) was dispersed in 20ml of 1,2-dichlorobenzene, then 2g of DDMAT was added, heated to 80°C and stirred for 24 hours, the reaction solution was poured into 200ml of methanol, and a brown precipitate was obtained by magnetic separation. The crude product was washed three times with methanol to remove unreacted DDMAT and dried in vacuo to obtain DDMAT-anchored Fe 3 o 4 Nanoparticles (nano-Fe 3 o 4 -DDMAT).

[0023] figure 1 is Fe 3 o 4 Infrared spectra of nanoparticles before and after anchoring DDMAT by ligand exchange reaction. In the infrared spectrum after exchange, at 1170cm -1 The -C(CH 3 ) 2 - The skeleton shock absorption peak; while the ex-exchange Fe 3 o 4 The stretching vibration absorption peak of C=C carried by oleic acid on the surface of nanoparticles basically disappeared, which proved that DDMAT was successfully ancho...

Embodiment 2

[0025] Example 2: Poly N-isopropylacryloyl-Fe 3 o 4 Preparation of hybrid magnetic nanoparticles

[0026] In a dry amp tube, 200 mg of nano-Fe 3 o 4 -DDMAT was dispersed in 10 mL of tetrahydrofuran, and then 1.85 g of N-isopropylacryloyl N-isopropylacryloyl and 1.17 mg of AIBN were added. After three cycles of "freezing-degassing-thawing", seal the tube, polymerize at 65°C for 10 hours, dilute the reaction solution with 10 mL of tetrahydrofuran, and then add 200 mL of anhydrous ether to form a suspension, and use magnetic separation to obtain poly-N-iso Propylacryloyl-Fe 3 o 4 Hybrid magnetic nanoparticles. The saturation magnetization of the obtained hybrid magnetic nanoparticles was 22.36 emu / g. The hybrid magnetic nanoparticles can be stably dispersed in water, and the particle size of the particles in the dispersion is 145nm as measured by dynamic light scattering. The aqueous dispersion is very stable, and there is no change when stored at 5°C for 6 months. The aq...

Embodiment 3

[0027] Example 3: Polystyrene-Fe 3 o 4 Preparation of hybrid magnetic nanoparticles

[0028] In a dry amp tube, 200 mg of nano-Fe 3 o 4 -DDMAT was dispersed in 10 mL of tetrahydrofuran, then 2.6 g of styrene and 2.34 mg of AIBN were added. After three cycles of "freezing-degassing-thawing", seal the tube, polymerize at 65°C for 47 hours, dilute the reaction solution with 10 mL of tetrahydrofuran, and then add 200 mL of anhydrous ether to form a suspension, and use magnetic separation to obtain polystyrene- Fe 3 o 4 Hybrid magnetic nanoparticles. The saturation magnetization of the obtained hybrid magnetic nanoparticles was 11.68 emu / g. The hybrid magnetic nanoparticles can be stably dispersed in common organic solvents such as tetrahydrofuran, and the particle diameter of the particles in the tetrahydrofuran dispersion measured by dynamic light scattering is 60nm, and the dispersion is very stable. Polystyrene-Fe 3 o 4 In hybrid magnetic nanoparticles, polystyrene an...

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Abstract

The invention discloses a method for anchoring RAFT chain transfer agent on the surface of Fe3O4 nanoparticles and a polymer-Fe3O4 hybrid magnetic nanoparticles preparation method. In the anchoring method of the invention, an ligand interchange reaction between the RAFT chain transfer agent and nano-Fe3O4 is performed to anchor the RAFT chain transfer agent S-1-dodecyl-S'-(alpha, alpha'-dimethyl- alpha''-acetic)trithiocarbonate (DDMAT) on the surface of nano-Fe3O4 in only one step, and the method has mild conditions and simple operation and does not change the particle size of Fe3O4 particles. Furthermore, polymer-Fe3O4 hybrid magnetic nanoparticles can be obtained by initiating controlled living radical polymerization of vinyl monomers in situ on the Fe3O4 nanoparticles with DDMAT. The invention selects styrene monomer and N-isopropylacrylamide monomer, the hybrid magnetic nanoparticles obtained from the former can be dissolved in the organic solvent; and the hybrid magnetic nanoparticles obtained from the latter can be dissolved in water and have temperature sensibility.

Description

technical field [0001] The invention relates to the field of magnetic materials, in particular to a polymer shell, nano-Fe 3 o 4 A method for preparing a hybrid magnetic nanoparticle as a core. Background technique [0002] Superparamagnetic nanoparticles are widely used in biomedical fields such as targeted drug delivery, nuclear magnetic resonance imaging contrast agents, hyperthermia, and bioseparation. Among many magnetic nanoparticles, nano-Fe 4 o 3 It is the most attractive because of its strong magnetism, relatively simple preparation and good biocompatibility. Due to the large specific surface area of ​​magnetic nanoparticles, they are easy to agglomerate and cause the performance of nano-effects to disappear, and the magnetic particles can only be used when they have a nanostructure, strong superparamagnetism, uniform particle size, water solubility and stability. Can be applied in the field of biotechnology. The surface modification of the magnetic nanopartic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/00H01F1/42C08F292/00
Inventor 卢江肖中鹏梁晖徐文烈
Owner SUN YAT SEN UNIV