MicroRNA-328 and application of antisense nucleotide thereof for diagnosing, preventing and curing heart diseases

A heart disease, nucleotide sequence technology, applied in the direction of cardiovascular system diseases, gene therapy, microbial determination/testing, etc.
CN101643791AInactive Publication Date: 2010-02-10HARBIN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN MEDICAL UNIVERSITY
Publication Date
2010-02-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a microRNA-328 and the application of antisense nucleotide thereof for diagnosing and controlling heart diseases; in the invention, a plurality of experiments prove that the microRNA-328 is changed and has pathopoiesia function in heavy heart diseases (atrial fibrillation, ischemia-reperfusion or myocardial fibrosis), and the antisense nucleotide AMO-328 of the microRNA-328has prevention and cure functions to the heart diseases, the microRNA-328 is used as a novel drug effect target spot, so as to finally determine and detect that the peripheral blood microRNA-328 canbe used as a novel biological marker which is used for diagnosing and preventing the heart diseases; in addition, the peripheral blood microRNA-328 expression level of a patient can be detected through fluorescent quantitative PCR and the nanometer microballoon technology enhanced by silver staining, so as to be used for diagnosing and preventing the heart diseases such as atrial fibrillation, long QT syndrome, ischemia-reperfusion or myocardial fibrosis and the like.
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Description

technical field

[0001] The present invention relates to a new medical application of endogenous non-coding small RNAs, in particular to the application of microRNA-328 and its antisense nucleotides in the diagnosis and prevention of heart disease, belonging to the field of diagnosis, prevention and treatment of heart disease . Background technique

[0002] Heart disease is a highly prevalent disease with high morbidity, mortality, and resulting socioeconomic burden. Regarding the prevention, diagnosis and treatment of heart disease, there are still huge gaps. Atrial fibrillation, ischemia-reperfusion arrhythmia, and long QT syndrome are the main manifestations of clinical heart disease. The current treatment effect is not good, and the mortality rate is high.

[0003] As a major pathological cause, myocardial fibrosis is involved in many heart diseases such as heart failure and arrhythmia. The pathogenesis of heart disease is complex, each pathogenesis can lead to one or ...

Claims

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