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Bionic enzymatic hydrolysate for scorpion and application thereof

A technology of biomimetic enzymolysis and products, applied in the field of biomimetic enzymolysis products, can solve the problems that cannot be fundamentally solved and affect the curative effect, etc., and achieve the effects of rapid onset of action, fast transdermal absorption, and enhanced curative effect

Inactive Publication Date: 2010-02-17
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using a single gastric enzyme or pancreatin or other single protease to enzymatically hydrolyze, although some small peptides can be obtained, none of them can fully enzymolyze the protein into small peptides, which greatly affects its curative effect
Therefore these enzymatic hydrolysis methods all can not fundamentally solve the problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Take 50g of fresh scorpion, add 10 times the amount of water to homogenate, adjust the pH to 2.0, add pepsin with 1% of the amount of scorpion, incubate at 40°C for 2 hours, adjust the pH to 8.0, add 1% of the amount of trypsin Enzyme or trypsin hydrolysis at 50°C for 5 hours, spray drying, adding an appropriate amount of starch, granulating, drying, sizing, and filling into capsules.

Embodiment 2

[0104] Take 50g of dried scorpion, crush it into 100 mesh fine powder, add 5 times the amount of water to homogenate, adjust the pH to 2.5, add pepsin with 1% of the amount of scorpion, keep it at 40°C for 2 hours, adjust the pH to 7.5, add 2% trypsin or trypsin in the whole scorpion was incubated at 50°C for 6 hours, spray-dried, added an appropriate amount of microcrystalline cellulose, granulated, dried, granulated, and compressed into tablets.

Embodiment 3

[0106] Take 50g of scorpion superfine powder, add 10 times the amount of water to homogenate, adjust the pH to 3.0, add pepsin with 1% of the amount of scorpion, incubate at 40°C for 2 hours, adjust the pH to 8.0, add 1% of the amount of scorpion Trypsin or trypsin is incubated at 50°C for 4 hours, heated to 85°C and incubated for 15 minutes, filtered, and the filtrate is ultrafiltered with an ultrafiltration membrane, and the solution with a molecular weight cut-off of 5kD or less is separated to make an injection.

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PUM

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Abstract

The invention discloses bionic enzymatic hydrolysate for scorpion and application thereof, and belongs to the field of Chinese medicaments. The invention adopts the technical scheme that: a bionic enzymolysis method is adopted; the scorpion is taken; and after water is added in the scorpion so as to form homogenate, under proper conditions, the heat preserving enzymolysis is carried out firstly bypepsin, and then the heat preserving enzymolysis is carried out by pancreatin or trypsase. The obtained enzymatic hydrolysate is prepared into preparations according to different preparation requirements. The bionic enzymatic hydrolysate has excellent effects in aspects of treating cardiovascular and cerebrovascular diseases, tumors, rheumatism, epilepsia and the like.

Description

technical field [0001] The invention relates to a biomimetic enzymatic hydrolysis product of the traditional Chinese medicine Scorpio and the medicinal application of the enzymatic hydrolysis product. It belongs to the field of traditional Chinese medicine. Background technique [0002] Scorpio is a kind of medicinal material recorded in the Chinese Pharmacopoeia. It has the functions of promoting blood circulation and removing blood stasis, calming wind and spasm, attacking poison and dispelling stagnation, dredging collaterals and relieving pain. Arthralgia, epilepsy, migraine headache, sores, scrofula. Scorpio was first recorded in the Five Dynasties "Shu Materia Medica", which has the functions of relieving fire and spasm, dispelling wind and attacking poison. Since modern research shows that earthworm has pharmacological activities such as promoting blood circulation, removing blood stasis, anti-tumor, dredging collaterals and relieving pain, the medicinal use of scor...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P9/00A61P25/08A61P29/00A61P35/00C12P21/00A61K35/646
Inventor 魏永利张加余
Owner 北京凯瑞创新医药科技有限公司
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