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Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis

A technology for inhibiting cells and compositions, which is applied in the field of medicine, can solve the problem of the composition inhibiting cell apoptosis, and achieve the effect of inhibiting cell apoptosis

Inactive Publication Date: 2010-02-24
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are reports on the treatment of apoplexy with the above composition, the treatment of apoplexy is the result, and it is not specified which one or several links or targets are used to treat apoplexy, nor is it found that the above composition inhibits cell apoptosis report

Method used

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  • Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis
  • Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis
  • Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Weigh the following Chinese medicine ingredients (unit: g):

[0056] Red ginseng 6 Panax notoginseng 9.0 Angelica 5.5 Caulis Spatholobus 7.8 Salvia 8.5

[0057] Safflower 5.5 Ginkgo Leaf 9.0 Hawthorn 7.8 Chrysanthemum 6.0 Cassia 5.9

[0058] Polygonum multiflorum 7.5 Shichangpu 5.1 Pueraria 7.6

[0059] Its production steps are:

[0060] 1. Take 4g of red ginseng and 6g of Panax notoginseng, crush them, pass through an 80-mesh sieve, and sterilize to obtain intermediate product A;

[0061] 2. The remaining red ginseng 2g, Panax notoginseng 3g, Ginkgo biloba 9.0g, and Salvia miltiorrhiza 8.5g were reflux extracted with 4 times the amount of 70% ethanol for 2 hours, and the ethanol was recovered from the alcohol extract to obtain the intermediate product B;

[0062] 3. The medicinal dregs of the alcohol extraction part and Angelica 5.5g, Miltonia 7.8g, Safflower 5.5g, Hawthorn 7.8g, Chrysanthemum 6.0g, Cassia 5.9g, Polygonum multiflorum 7.5g, Shichangpu 5.1g, Pueraria ...

Embodiment 2

[0065] Weigh the following Chinese medicine ingredients (unit: g):

[0066] Red ginseng 8 Panax notoginseng 10 Angelica 6 Spatholobus 8.2 Salvia 9.2

[0067] Safflower 5.8 Ginkgo Leaf 9.5 Hawthorn 8.1 Chrysanthemum 6.6 Cassia 6.6

[0068] Polygonum multiflorum 8.0 Shichangpu 5.5 Pueraria 7.9

[0069] Its production steps are:

[0070] 1. Take 8g of red ginseng, 10g of Panax notoginseng, 9.5g of ginkgo biloba, 9.2g of salvia miltiorrhiza and reflux extract with 4.5 times the amount of 60% ethanol for 2 hours, recover ethanol from the alcohol extract to obtain intermediate product B 1 ;

[0071] 2. The dregs of the alcohol extraction part and Angelica 6g, Millipeda 8.2g, Safflower 5.8g, Hawthorn 8.1g, Chrysanthemum 6.6g, Cassia 6.6g, Polygonum multiflorum 8.0g, Shichangpu 5.5g, Pueraria 7.9g, etc. Add 8 times the amount of water to extract the nine medicinal materials together twice, each time for 2 hours, to obtain the extract, and B 1 Partially mixed and concentrated to o...

Embodiment 3

[0074] Weigh the following Chinese medicine ingredients (unit: g):

[0075] Red Ginseng 10 Panax notoginseng 8 Angelica 7 Spatholobus 8.5 Salvia 10.2

[0076] Safflower 6.5 Ginkgo Leaf 10 Hawthorn 8.2 Chrysanthemum 6.5 Cassia 6.2

[0077] Polygonum multiflorum 8.5 Shichangpu 5.3 Pueraria 8.3

[0078] Its production steps are:

[0079] 1. Take 10g of red ginseng, 8g of notoginseng, 10g of ginkgo biloba, 10.2g of salvia miltiorrhiza and extract with 7 times the amount of 50% ethanol for 2-3 hours, recover ethanol from the alcohol extract to obtain intermediate product B 2 ;

[0080] 2. The medicinal dregs of the alcohol extraction part and 7g of angelica, 8.5g of spatholobus, 6.5g of safflower, 8.2g of hawthorn, 6.5g of chrysanthemum, 6.2g of chrysanthemum, 8.5g of Polygonum multiflorum, 5.3g of Shichangpu, 8.3g of kudzu root, etc. Add 8 times the amount of water to the nine medicinal materials and extract twice, each time for 2 hours, to obtain the extract, mix with part B2...

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Abstract

The invention discloses the use of a Chinese medicinal composition in the preparation of medicaments for inhibiting cell apoptosis. The medicament is mainly prepared from the following main active rawmaterials in percentage by weight: red ginseng 6.05-15.8, panax pseudo-ginseng wall 8.95-10.08, Chinese angelica 5.12-8.34, suberect spatholobus stem 7.76-8.97, salvia miltiorrhiza bunge 8.01-11.13,safflower 5.18-8.84, ginkgo leaf 8.87-10.11, hawthorn 7.76-8.55, chrysanthemum 5.78-6.89, sea-ear shell 5.80-6.53, tuber fleeceflower root 7.77-8.84, grassleaf sweelflag rhizome 5.03-5.74, and kudzu-vine root 7.56-8.65. The Chinese medicinal composition has the function of inhibiting the cell apoptosis, thereby being capable of treating diseases related to cell apoptosis. The Chinese medicinal composition is a novel targeted medicament for treating diseases related to cell apoptosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a known traditional Chinese medicine composition in the preparation of drugs for inhibiting apoptosis. Background technique [0002] Apoptosis is one of the processes or modes of cell death proposed by Kerr, Wyllie', Currie et al. (see Brit, J. Cancer, 26, 239 (1972)). It is already known in embryology that cell death inevitably occurs at a certain place during a certain period of embryogenesis, and it is also called "programmed cell death" in the sense that cell death occurs along with the occurring program. Therefore, it is morphologically different from the process in which necessary cells are hindered and necrotic. Morphological features of apoptosis include lack of contact with surrounding cells, condensation of cytoplasm, condensation of chromatin and nuclear condensation associated with endonuclease activity, and segmentalization of the nucleus etc....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P7/02A61P9/04A61P9/06A61P9/10A61P25/16A61P25/28A61K35/56
Inventor 邹节明王征
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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