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Tissue engineering tendon compound support material as well as preparation method and application thereof

A composite scaffold and tissue engineering technology, used in scaffolds, medical science, prostheses, etc., can solve the problems of difficult surgical suturing, tissue-engineered tendons can not meet the mechanical requirements of in vivo transplantation, etc.

Active Publication Date: 2013-01-23
SHANGHAI JURUI BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these tendons were in a fibrous or semi-solid state in the early stage, and it was difficult to perform surgical suturing; the rapid degradation of PGA made the constructed tissue-engineered tendons far from meeting the mechanical requirements of in vivo transplantation

Method used

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  • Tissue engineering tendon compound support material as well as preparation method and application thereof
  • Tissue engineering tendon compound support material as well as preparation method and application thereof
  • Tissue engineering tendon compound support material as well as preparation method and application thereof

Examples

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preparation example Construction

[0051] The preparation method of composite support material provided by the invention comprises steps:

[0052] (a) braiding polyglycolic acid fibers and polylactic acid fibers with a fiber root number ratio of 0.5-6:2 into braided threads;

[0053] (b) weaving the braided yarn into a tubular knitted fabric; and

[0054] (c) Filling the polyglycolic acid non-woven cotton into the tubular knitted fabric to obtain the tissue-engineered tendon composite scaffold material.

[0055] In a preferred example of the present invention, comprise the following steps:

[0056] A1. Weave PGA fiber filaments and PLA fiber filaments on a braiding machine according to a certain number (greater than or equal to 3) and ratio (0.8—5:2) to form a braided wire; the parameters are: PGA fiber filament 5.1tex, PLA Fiber filament 8.4tex, 6-strand diamond-shaped weave structure (as attached figure 2 (A)), the synthetic count range of ply line is 31.2—58.5tex;

[0057] A2, weave the above-mentioned ...

Embodiment 1

[0083] Preparation of Composite Scaffold Material I

[0084] Weave 2 PGA fiber filaments and 4 PLA fiber filaments into a braided wire on a braiding machine. The parameters are: the fineness of the PGA fiber filaments is 5.1tex, the fineness of the PLA fiber filaments is 8.4tex, and the number of spindles of the braiding machine is 6 spindles, the number of gear teeth is 30, the weaving angle is 60°, and the diamond weaving structure is adopted. Then weave the braided thread into a tubular knitted fabric on a small-diameter weft knitting machine. The parameters are: the braided thread is 55.8 tex, the total needle number of the knitting machine is 14 needles, the knitting needle is a latch needle, and the inner diameter of the needle cylinder is 17 mm. The outer diameter is 21mm, the negative single-way yarn feeding, the yarn feeding tension is 0.1cN, the weight is pulled, the weight of the weight is 420g, the yarn bending depth is 1.5mm, and the weave structure is weft flat n...

Embodiment 2

[0086] Preparation of Composite Scaffold II

[0087]Weave 4 PGA fiber filaments and 2 PLA fiber filaments on a braiding machine to form a braided wire. The parameters are: the fineness of the PGA fiber filaments is 5.1tex, the fineness of the PLA fiber filaments is 8.4tex, and the number of spindles of the braiding machine is 6 spindles, the number of gear teeth is 30, the weaving angle is 60°, and the diamond weaving structure is adopted. Then weave the braided thread into a tubular knitted fabric on a small-diameter weft knitting machine. The parameters are: the braided thread is 45.6 tex, the total number of needles of the knitting machine is 14 needles, the knitting needle is a latch needle, and the inner diameter of the needle cylinder is 17 mm. The outer diameter is 21mm, the negative single-way yarn feeding, the yarn feeding tension is 0.1cN, the weight is pulled, the weight of the weight is 420g, the yarn bending depth is 1.5mm, and the weave structure is weft flat nee...

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Abstract

The invention discloses a tissue engineering tendon compound support material. The compound support material comprises (1) tubular knit fabric and (2) non-woven cotton filled in the tubular knit fabric; the tubular knit fabric is composed of PGA fiber and PLA fiber with number ratio being 0.5-6:2. The invention also discloses a preparation method and application of the compound support material.

Description

technical field [0001] The invention relates to a tissue engineering scaffold material, in particular to a tissue engineering tendon composite scaffold material and its preparation method and application. Background technique [0002] The repair of tendon defects is one of the difficult problems in hand surgery and plastic and reconstructive surgery. The main reasons are the lack of suitable tendon grafts and poor tendon self-healing ability. Autologous tendon transplantation is the main repair method at present, but the source of autologous tendon is limited, and the dysfunction of the donor site is unavoidable; allogeneic tendon transplantation has problems such as disease infection and immune rejection. [0003] Since 1953, people began to use materials such as alloys, plastics, and synthetic fibers to make artificial tendons. Due to various reasons, some materials are pulled off by the muscle movement of the autogenous tendon, and finally the sutures are torn off; Pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61F2/90A61F2/82
Inventor 刘伟张佩华曹谊林崔磊王斌邓丹
Owner SHANGHAI JURUI BIOMATERIALS