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Novel agents of calcium ion channel modulators

A hydrogen atom and solvate technology, applied in anti-inflammatory agents, non-central analgesics, metabolic diseases, etc.

Inactive Publication Date: 2010-03-31
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Known treatments for these diseases and disorders have many problems and side effects

Method used

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  • Novel agents of calcium ion channel modulators
  • Novel agents of calcium ion channel modulators
  • Novel agents of calcium ion channel modulators

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0071] Definition of Terms

[0072] "Alkyl" is used alone or as part of a substituent herein, and specifically refers to a straight chain, branched chain or single-bond ring substituent containing 0 or 1 or more unsaturated bonds in the middle. Representative examples include, but are not limited to, methyl, ethyl (including ethyl, vinyl, and ethynyl), propyl (including 1-propanyl, 2-propanyl, cyclopropanyl, 1 or 2- propenyl, allyl, 1 or 2-cyclopropenyl, and 1 or 2-propynyl), butyl (1 or 2-butanyl, 2-methyl-1 or 2-propanyl, cyclobutanyl Alkyl, 1-en-butyl, 1-en-2-butyl, 2-methyl-1-en-propyl, 2-en-1-butyl, 2-en-2-butyl, 1 , 3-diene-1-butyl, 1,3-diene-2-butyl, 1-ene-cyclobutyl, 1-ene-3-cyclobutyl, 1,3-diene-1- cyclobutyl, 1-yn-butyl, 1-yn-3-butyl, 3-yn-1-butyl, etc.), and other similar longer carbon chains.

[0073] Here, the term "alkyl" refers specifically to saturated and unsaturated carbon chains. For example, a carbon chain containing only single bonds, a group containin...

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Abstract

The present invention includes a group of chemical compounds useful as modulators of calcium ion (Ca2+) channels, especially for T-type, N-Type and L-type channels. The present invention also includespharmaceutical compositions comprising these calcium ion channel modulating agents and methods of using these calcium ion channel modulating agents for the treatment diseases and conditions associated with the calcium ion channels.

Description

[0001] Cross reference to related applications [0002] This application claims priority to US Provisional Application 60 / 894,368, filed March 12, 2007, which is hereby incorporated by reference in its entirety as a part of this disclosure. field of invention [0003] The present invention relates to a group of compounds for the regulation of calcium ions (Ca 2+ ) channels, especially T, N and L type calcium ion channel modulators and pharmaceutical compositions for preventing and treating diseases related to calcium ion channels. Background of the invention [0004] Calcium ions (Ca 2+ ) channels are multi-subunit transmembrane proteins. This protein makes Ca 2+ Influx from the cell's external environment and concomitant depolarization of the cell's membrane potential play a central role in the release of neurotransmitters. Traditionally, calcium channels are generally classified based on their functional characteristics, such as low or high voltage activation of calci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00
CPCC07D401/14C07D487/04C07D491/08C07D405/12C07D409/14A61P1/00A61P25/00A61P25/08A61P25/16A61P25/18A61P25/22A61P25/28A61P29/00A61P3/10A61P35/00A61P9/10A61P9/12
Inventor 吴节强郭建新L·T·阮
Owner VM DISCOVERY
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