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Metoprolol tartrate injection and preparation method thereof

A technology of metoprolol tartrate and injection, which is applied in the field of biochemical pharmacy and can solve problems such as short onset time

Inactive Publication Date: 2010-06-16
长春白求恩制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an emergency medicine, metoprolol tartrate injection is required to have a short onset time, but in actual use, the onset time is generally more than 8.9 minutes

Method used

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  • Metoprolol tartrate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] It is prepared by adding 1 g of metoprolol tartrate, 9 g of sodium chloride, 10 ml of absolute ethanol, 3 g of poloxamer 188, and water for injection to 1000 ml.

[0021] Its preparation method is as follows:

[0022] Add 70% of the total volume of water for injection to the prescribed amount of metoprolol tartrate, add the prescribed amount of sodium chloride, absolute ethanol, poloxamer 188, appropriate amount of activated carbon, add water for injection to 1000ml, and decarbonize Filtration, detection of intermediates, filling, 121 ° C, 20 minutes of moist heat sterilization, leak detection, light inspection, finished product packaging.

Embodiment 2

[0024] It is prepared by adding 1 g of metoprolol tartrate, 7 g of sodium chloride, 15 ml of absolute ethanol, 2 g of poloxamer 188, and water for injection to 1000 ml.

[0025] Its preparation method is as follows:

[0026] Add 80% of the total volume of water for injection to the prescribed amount of metoprolol tartrate, add the prescribed amount of sodium chloride, absolute ethanol, poloxamer 188, appropriate amount of activated carbon, add water for injection to 1000ml, and decarbonize Filtration, detection of intermediates, filling, 121 ° C, 20 minutes of moist heat sterilization, leak detection, light inspection, finished product packaging.

Embodiment 3

[0028] Prepare by adding 1 g of metoprolol tartrate, 6 g of sodium chloride, 12 ml of absolute ethanol, 1 g of poloxamer 188, and water for injection to 1000 ml.

[0029] Its preparation method is as follows:

[0030] Add 80% of the total volume of water for injection to the prescribed amount of metoprolol tartrate, add the prescribed amount of sodium chloride, absolute ethanol, poloxamer 188, an appropriate amount of activated carbon, add water for injection to the full amount, and decarbonize Filtration, detection of intermediates, filling, 121 ° C, 20 minutes of moist heat sterilization, leak detection, light inspection, finished product packaging.

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Abstract

The invention discloses a metoprolol tartrate injection and a preparation method thereof. The metoprolol tartrate injection is prepared from the following components: 1g metoprolol tartrate, 9g of sodium chloride, 10 to 15ml of absolute ethanol, 1 to 3g of poloxamer 188 and 1,000ml of water for injection. The metoprolol tartrate injection and the preparation method thereof use the ethanol and the surfactant poloxamer to promote the transfer of the metoprolol between lipid substances in blood and tissues; and the synergistic effect shortens the onset time of the metoprolol tartrate to about 6.4 minutes so as to win more than 3 minutes of precious time for a patient with acute myocardial infarction.

Description

technical field [0001] The invention relates to the improvement of the drug formula for cardioselective beta-receptor blockade, in particular discloses a metoprolol tartrate injection and a preparation method thereof, belonging to the technical field of biochemical pharmacy. Background technique [0002] Metoprolol tartrate injection is used for the treatment of the following diseases: supraventricular tachyarrhythmia, prevention and treatment of myocardial ischemia, suspected or confirmed acute myocardial infarction with tachyarrhythmia and chest pain. As an emergency medicine, metoprolol tartrate injection is required to have a short onset time, but in actual use, the onset time is generally more than 8.9 minutes. Further shortening the onset time will save more patients. Invention content: [0003] The invention discloses a metoprolol tartrate injection, which can further shorten the onset time of the medicine and win precious time for the rescue of patients. [0004]...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/138A61K47/34A61P9/06A61P9/10A61K47/10
Inventor 王巍
Owner 长春白求恩制药有限公司
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