Method for detecting light source distribution in target based on level set

Abstract

The invention relates to a method for detecting light source distribution in a target based on a level set, which uses the method of using the emergent light intensity distribution on the surface of the target captured by a high-performance CCD camera, using the forward model of the approximate diffusion equation of the first-order spherical harmonic equation of the Boltzmann Equation, and using the level set as a detection light source. The method comprises: controlling the position of the distribution of the light source to be detected and the distribution by using a partitioned constant function, controlling the partitioned constant value in the light source value in each subregion, synchronously combining an operator decomposition technique and a gain Lagrange technique to enhance theefficiency of the detection technique, positioning and quantifying the light source, and detecting the distribution region of the light source. The method is not sensitive to noise and initial valuesin the detection process, can detect a reliable result when the number of levels of the level set is not known, and has strong robustness. The technique can be effectively applied to the conditions that an imaging system has relatively low performances or an experimental environment is relatively bad.

Description

technical field [0001] The invention belongs to the field of optical molecular imaging, and relates to quantitative information and image analysis of a detection light source, in particular to a level set-based detection method of light source distribution in a target body. Background technique [0002] Optical molecular imaging is a technology that can realize non-invasive real-time dynamic imaging of biophysical processes inside biological tissues at the molecular level. Through the acquired light intensity distribution on the surface of the target, detecting the light source distribution inside the tissue can quantitatively study the research target and provide three-dimensional positioning information for the light source. [0003] Most of the commonly used detection techniques are based on traditional methods based on gradients. Because the signals of optical molecular images are very weak, the collected data sets are noisy. The selection of the value, the selection of...

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Problems solved by technology

[0005] In order to solve the weak signal of the traditional gradient-based optical molecular imaging method, the collected data set is noisy, which makes the selection of the initial value, the selection of the feasible region, and the tolerance of noise high during the detection process, which limits the optical The problem of molecular imaging application, the purpose of the present invention is to provide a method for detecting the distribution of target light source based on level set

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