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Isosorbide mononitrate controlled release tablet and preparation method thereof

A technology of isosorbide dinitrate and controlled-release tablets, which is applied in the field of medicine to achieve the effects of small fluctuations in blood drug concentration, stable drug release, and long-lasting drug effects

Active Publication Date: 2012-04-18
北京华素制药股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In vivo blood concentration drug effect Greater than 300 ng / ml Tolerance quickly develops with continuous medication Framing Method and Framing Mechanism

Method used

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  • Isosorbide mononitrate controlled release tablet and preparation method thereof
  • Isosorbide mononitrate controlled release tablet and preparation method thereof
  • Isosorbide mononitrate controlled release tablet and preparation method thereof

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preparation example Construction

[0039] figure 1 It is the flow chart of the preparation method embodiment of isosorbide mononitrate controlled-release tablet of the present invention. Such as figure 1 As shown, the method includes the following steps:

[0040] Step 10: preparing the core of the isosorbide mononitrate controlled-release tablet.

[0041] Described step 10 comprises the following steps:

[0042] Step 101: Pass isosorbide mononitrate and the first auxiliary material through a 40-70 mesh sieve respectively, and mix evenly;

[0043] Step 102: After passing the second auxiliary material through a 10-20 mesh sieve, add it to the uniformly mixed isosorbide mononitrate and the first auxiliary material, and mix evenly;

[0044] Step 103: Compress the uniformly mixed isosorbide mononitrate, first auxiliary material and second auxiliary material to form a tablet core.

[0045] Step 20: Prepare a coating solution, and coat the core of the isosorbide mononitrate controlled-release tablet.

[0046] Af...

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Abstract

The invention relates to an isosorbide mononitrate controlled release tablet which consists of a tablet core and a coating. The isosorbide mononitrate controlled release tablet comprises the following components in percentage by weight: 1-20 percent of isosorbide mononitrate, 30-90 percent of first auxiliary material and 9-50 percent of second auxiliary material. The invention also relates to a preparation method of the isosorbide mononitrate controlled release tablet. The preparation method comprises the following steps of: preparing the tablet core of the isosorbide mononitrate controlled release tablet; preparing coating liquid; and coating the tablet core of the isosorbide mononitrate controlled release tablet.

Description

technical field [0001] The invention relates to an isosorbide mononitrate controlled-release tablet and a preparation method thereof, belonging to the field of medicines. Background technique [0002] Isosorbide mononitrate is a commonly used drug for the treatment of coronary heart disease and angina pectoris. Its main mechanism of action is to expand venous volume vessels and peripheral resistance vessels, reduce cardiac preload and postload, and reduce myocardial oxygen consumption. At present, the dosage forms of isosorbide mononitrate include tablets, capsules and the like. [0003] It is of great significance to make isosorbide mononitrate into a sustained and controlled release preparation. The U.S. Food and Drug Administration (Food and Drug Administration, referred to as FDA) recommends an asymmetric time-interval administration method, such as taking one tablet of isosorbide mononitrate at 8 o'clock in the morning and at 3 o'clock in the afternoon, but in practice...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/34A61P9/10
Inventor 张丹魏淑冬边玢
Owner 北京华素制药股份有限公司
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