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Osmosis pump controlled release preparation containing Chinese medicine of cyclovirobuxine D, and preparing method thereof

A technology of cyclovir buxus and osmotic pump controlled release, which is applied in the field of traditional Chinese medicine formulations and can solve the problems of high equipment requirements, complicated preparation process of dual-chamber osmotic pump tablets, and difficulty in popularizing industrialized production.

Inactive Publication Date: 2005-02-02
BEIJING ZHONGHUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, the preparation process of dual-chamber osmotic pump tablets is complicated, requires high equipment, is expensive, and it is difficult to popularize industrial production. There is no dosage form of osmotic pump tablets for traditional Chinese medicine.

Method used

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  • Osmosis pump controlled release preparation containing Chinese medicine of cyclovirobuxine D, and preparing method thereof
  • Osmosis pump controlled release preparation containing Chinese medicine of cyclovirobuxine D, and preparing method thereof
  • Osmosis pump controlled release preparation containing Chinese medicine of cyclovirobuxine D, and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0053] Example 1: Weigh 3.0g of Cycloviral Buxus D, 25.0g of sodium chloride, 15.0g of sucrose, 12.0g of lactose, 23.0g of glucose, 26.0g of mannitol, 5.2g of succinic acid, 4.3g of sodium carboxymethyl starch, paste Refined 12.0g, polyethylene oxide 1.5g.

[0054] The above components are passed through 80 mesh sieve respectively, and mixed evenly. Granulate with 20% polyvinylpyrrolidone ethanol solution, pass through a 20-mesh sieve and dry in an oven at 60° C. for 18 hours. After taking out, granulate with 20 mesh sieves, add 1% magnesium stearate as a lubricant, and press it into a tablet core with a hardness of 90-100N.

[0055] Weigh 5.5g of carboxypropylmethylcellulose, 4.8g of cellulose acetate, and 0.5g of polyethylene glycol, and dissolve them in 200ml of acetone. The obtained coating solution is evenly applied on the tablet core, so that the weight gain is 6.5 mg / tablet to 8.0 mg / tablet. A small hole with a diameter of 0.4 mm to 0.8 mm is punched on both sides of...

example 2

[0056] Example 2: Weigh 4.0g of Cycloviral Buxus D, 45.0g of sodium chloride, 30.0g of sucrose, 24.0g of lactose, 30.0g of glucose, 40.0g of mannitol, 5.6g of tartaric acid, 4.5g of carmellose, carboxymethylcellulose Sodium starch glycolate 6.0g, dextrin 20.0g, polyethylene oxide 2.5g.

[0057] The above components are passed through 80 mesh sieve respectively, and mixed evenly. Granulate with 20% polyvinylpyrrolidone ethanol solution, pass through a 20-mesh sieve and dry in an oven at 60° C. for 18 hours. After taking out, granulate with 20 mesh sieves, add 1% magnesium stearate as a lubricant, and press it into a tablet core with a hardness of 90-100N.

[0058] Weigh 6.5g of carboxypropylmethylcellulose, 5.8g of cellulose acetate, and 1.5g of polyethylene glycol, and dissolve them in 300ml of acetone. The obtained coating solution is evenly applied on the tablet core, so that the weight gain is 6.5 mg / tablet to 7.5 mg / tablet. A small hole with a diameter of 0.4 mm to 0.8 ...

example 3

[0059] Example 3: Weigh 6.0g of Cycloviral Buxusin D, 65.0g of sodium chloride, 40.0g of sucrose, 36.0g of lactose, 35.0g of glucose, 60.0g of mannitol, 9.6g of sodium dihydrogen phosphate, and 5.5g of carmellose , sodium carboxymethyl starch 8.0g, dextrin 32.0g, polyethylene oxide 4.5g.

[0060] The above components are passed through 80 mesh sieve respectively, and mixed evenly. Granulate with 20% polyvinylpyrrolidone ethanol solution, pass through a 20-mesh sieve and dry in an oven at 60° C. for 18 hours. After taking out, granulate with 20 mesh sieves, add 1% magnesium stearate as a lubricant, and press it into a tablet core with a hardness of 90-100N.

[0061] Weigh 6.5g of carboxypropylmethylcellulose, 7.8g of cellulose acetate, and 1.75g ​​of polyethylene glycol, and dissolve them in 300ml of acetone. The obtained coating solution is uniformly applied on the tablet core, so that the weight gain is 5.5 mg / tablet to 6.5 mg / tablet. A small hole with a diameter of 0.4 mm...

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PUM

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Abstract

A controlled release medicine containing the Chinese-medicinal component cyclovirobuxine D is composed of the core tablet consisting of cyclovirobuxine D, penetrating active substance, acidic substance and high-molecular compound, and the coating film prepared from high-molecular compound. Its advantage is constant release speed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formulations, and particularly relates to a controlled-release preparation prepared by applying modern preparation technology to the traditional Chinese medicine monomer cyclovirbuxine D. Background technique [0002] Cyclovitamin D is an effective monomer component extracted from the traditional Chinese medicine Boxwood, and it is a plant-based monomer drug used to treat cardiovascular and cerebrovascular diseases. At present, its ordinary tablets are often used clinically, which can treat ischemic cardiovascular and cerebrovascular diseases, rheumatic heart diseases, improve coronary circulation, reduce myocardial oxygen consumption, significantly relieve angina pectoris, improve cerebral circulation and regulate blood pressure, etc. Inotropic and antiarrhythmic effects. However, animal experiments have shown that when conventional preparations of Cyclovirubuxin D (0.5 mg / t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/565A61P9/10
Inventor 郝东荣赵煜陈军梁秉文马建国朱德权
Owner BEIJING ZHONGHUI PHARM CO LTD
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