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Artesunate compound medicine composition with improved mouth feeling and high stability

A technology of artesunate and composition, which is applied in the field of preparations, can solve problems affecting the stability of artesunate, etc., and achieve the effect of fast onset, improved release speed, and good taste

Inactive Publication Date: 2010-06-30
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both alkaline substances and amodiaquine hydrochloride were found to affect the stability of artesunate

Method used

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  • Artesunate compound medicine composition with improved mouth feeling and high stability
  • Artesunate compound medicine composition with improved mouth feeling and high stability
  • Artesunate compound medicine composition with improved mouth feeling and high stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]

[0041] Process:

[0042] Granule 1: mix artesunate, lactose, and starch evenly, granulate 10% starch slurry, dry at 50°C, take 24-60 mesh granules, and set aside.

[0043] Granule 2: Mix amodiaquine hydrochloride, lactose, and starch evenly, granulate with appropriate amount of water, dry at 60°C, take 24-60 mesh granules, coat with 6% HPMC E5 and 50% ethanol to increase the weight by 20%.

[0044] Granule 3: Mix sodium bicarbonate, lactose, and starch evenly, granulate with 50% ethanol, dry at 40°C, get 24-60 mesh granules, coat with 50% ethanol with 6% HPMC E5 to increase the weight by 20%.

[0045] Measure the content of granule 1, granule 2 and granule 3, pack artesunate 25mg, amodiaquine 67.5mg, sodium bicarbonate 32mg per bag.

Embodiment 2

[0047]

[0048] Granule 1: Mix artesunate, lactose, and starch evenly, granulate with 10% starch slurry, dry at 50°C, take 24-60 mesh granules, coat with 20% dextran, and increase the weight of the coating by 20%.

[0049] Granule 2: Mix amodiaquine hydrochloride, lactose, and starch evenly, granulate with appropriate amount of water, dry at 60°C, take 24-60 mesh granules, and set aside.

[0050] Granule 3: Mix sodium bicarbonate, lactose, and starch evenly, granulate with 50% ethanol, dry at 40°C, take 24-60 mesh granules, and set aside.

[0051] Measure the content of granule 1, granule 2 and granule 3, pack artesunate 25mg, amodiaquine 67.5mg, and sodium carbonate granules 20mg per bag.

Embodiment 3

[0053]

[0054]

[0055] Granule 1: Mix artesunate, lactose, and starch evenly, granulate 10% starch slurry, dry at 50°C, and take 24-60 mesh granules

[0056] Granule 2: Mix amodiaquine hydrochloride, lactose, and starch evenly, granulate with appropriate amount of water, dry at 60°C, take 24-60 mesh granules, coat with 20% PVP K29 / 32 aqueous solution, and increase the weight of the coating by 20%.

[0057] Granule 3: Mix sodium bicarbonate, lactose, and starch evenly, granulate with 50% ethanol, dry at 40°C, take 24-60 mesh granules, and coat with 20% PVP K29 / 32 aqueous solution, and the weight gain of the coating is 20%.

[0058] Measure the content of granule 1, granule 2 and granule 3, pack artesunate 25mg, amodiaquine 67.5mg, sodium bicarbonate 32mg per bag.

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Abstract

The invention belongs to the field of preparations, in particular to an artesunate compound medicine composition with improved mouth feeling and high stability. The invention is characterized in that 1) the artesunate compound medicine composition comprises three kinds of granules: artesunate granules, alkaline matter granules and camoquin granules; and 2) the lagging cover is realized through polymer materials, and the artesunate granules are separated from the alkaline matter granules and the camoquin granules. The medicine composition improves the release speed of the artesunate, inhibits the bitterness of the camoquin, and simultaneously maintains the stability of the artesunate.

Description

technical field [0001] The invention belongs to the field of preparations, and in particular relates to a pharmaceutical composition that improves taste and is stable, including 1) containing three kinds of granules: artesunate granules, alkaline substance granules, and amodiaquine hydrochloride granules; 2) The artesunate granules are separated from the alkaline substance granules and amodiaquine hydrochloride granules by the polymer material coating. The pharmaceutical composition improves the release speed of artesunate and the bitter taste of amodiaquine hydrochloride, while maintaining the stability of artesunate. Background of the invention: [0002] Malaria is one of the most common diseases in the tropics and subtropics. Malaria morbidity and mortality remain high in many third world countries. Malaria is still distributed in more than 100 countries and regions around the world. In 1998, WHO estimated that 300-500 million people in the world contracted malaria eve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4706A61K31/357A61K47/02A61P33/06
Inventor 王显著王海屿邓杰张涛牟才华
Owner CHONGQING PHARMA RES INST
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